Method for preparing throat care powder

The technology of Hukang powder and Kangsan is applied in the field of preparation of Hukang powder, which can solve the problems such as the total number of bacteria, the total number of molds, Escherichia coli exceeding the standard, and the drug storage process is unstable, so as to ensure the effect of medication, easy industrial production, good effect

Active Publication Date: 2018-03-16
黑龙江参鸽药业有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no limit on the content of the active ingredients of Houkang powder, and the clinically used Houkang powder is made by crushing and mixing the medicinal materials. The powder of the medicinal materials is directly used as medicine, which leads to the instability of the drug during storage. The total number of bacteria, The total number of molds, Escherichia coli, etc. are easy to exceed the standard

Method used

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  • Method for preparing throat care powder
  • Method for preparing throat care powder
  • Method for preparing throat care powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]Embodiment 1 Preparation of Houkang Powder of the present invention

[0037] Prescription: 37.5 parts of borneol, 87.5 parts of pearl layer powder, 62.5 parts of raw sun-dried ginseng, 200 parts of borax, 250 parts of Xuanming powder, 62.5 parts of menthol, 250 parts of trichosanthin, 62.5 parts of Andrographis paniculata, 125 parts of Qingdai, 62.5 parts of licorice.

[0038] Step 1: Extraction of andrographis paniculata, raw sun-dried ginseng and trichosanthes

[0039] Take the above raw materials, crush them, add 80% ethanol to reflux heating and extracting three times, add 10 times the amount of 80% ethanol for the first time, extract for 2 hours, add 5 times the amount of 80% ethanol for the second time, heat at 60°C, and extract for 2 hours , combined ethanol extracts, filtered, and the filtrate was decompressed to recover ethanol and concentrated to a thick paste with a relative density of 1.30-1.40 (50°C), dried under reduced pressure to obtain the extracts of An...

Embodiment 2

[0048] Embodiment 2 The content of Houkang powder active ingredient of the present invention

[0049] Experimental method: the total amount of andrographolide and dehydroandrographolide, indirubin, and ginsenoside Rg were added to Houkang powder prepared in Example 1. 1 and the total amount of ginsenoside Re and ginsenoside Rb 1 As the active ingredient, the content determination is carried out according to the following detection methods.

[0050] 1. Content Determination of Andrographolide and Dehydroandrographolide

[0051] Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel was used as filler; methanol-water (52:48) was used as mobile phase; the detection wavelength of andrographolide was 225nm, and the detection wavelength of dehydroandrographolide was 254nm. The number of theoretical plates should be no less than 2000 based on the peaks of andrographolide and dehydroandrographolide.

[0052] Preparation of reference substance sol...

Embodiment 3

[0069] Embodiment 3 Houkang powder of the present invention is on the impact of chronic pharyngitis rats

[0070] 1. Experimental animals: 60 3-month-old SD rats, half male and half male, weighing 200±20g.

[0071] 2. Test drug: the Houkang powder of the present invention prepared in Example 1, and the positive control drug is a commercially available Houkang powder (hereinafter referred to as the positive control drug).

[0072] 3. Modeling

[0073] 60 rats are divided into 6 groups at random, and every group of 10 (half male and half female) are respectively used as blank control group, model group, positive control drug, low-dose group of Houkang powder of the present invention, middle-dose group of Houkang powder of the present invention, Houkang powder high dose group of the present invention. Except the blank group, the other 60 rats were modeled. At the beginning of modeling, put ammonia water with a concentration of 2.5% into the nebulizer, and spray pharynx to 60...

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Abstract

The invention provides a method for preparing throat care powder. By adopting the method, medicinal materials are extracted, medicines are relatively stable in the storage process while medicinal effects are ensured, and in addition, the contents of effective components are defined. The method comprises the following steps: 1, preparing extracts of common andrographis herb, sun-dried ginseng and radix trichosanthis; 2, preparing an extract of licorice roots; 3, preparing an extract of indigo naturalis; 4, uniformly mixing the extracts obtained in the steps 1-3, and crushing so as to obtain extremely fine powder; 5, grinding and uniformly mixing the extremely fine powder obtained in the step 4 with a compound of glauber-salt and liquorice, fine borax and fine borneol, and further uniformlymixing with pearl layer powder; and 6, grinding the medicinal powder obtained in the step 5 with menthol in a mortar by using an equivalent incremental method, uniformly mixing, and screening, therebyobtaining the throat care powder.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of Houkang Powder. 2. Background technology [0002] Houkang San is a Chinese patent medicine used to treat oral and throat diseases. It is used for various throat diseases, such as acute and chronic pharyngitis, posterior inflammation, tonsillitis, oral ulcers, etc. Use powder injection to administer, spray the throat for throat diseases, and spray the affected area for oral ulcers, appropriate amount each time, 2 to 3 times a day. [0003] The standard of Houkang Powder is recorded in the Ministry of Health of the People's Republic of China Drug Standards of Traditional Chinese Medicine Prescriptions Volume 5, standard number WS 3 -B-1040-91. It consists of 10 herbs, namely 37.5g borneol, 87.5g pearl layer powder, 62.5g sun-dried ginseng, 200g borax (calcined), 250g Xuanming powder, 62.5g menthol, 250g trichosanthin, 62.5g Andrographis pan...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K36/484A61K9/14A61P1/02A61P11/04A61K31/045A61K33/04A61K33/22A61K35/618
CPCA61K9/14A61K31/045A61K33/04A61K33/22A61K35/618A61K36/19A61K36/195A61K36/258A61K36/315A61K36/428A61K36/484A61K36/704A61K2236/333A61K2236/37A61K2236/39A61K2236/51A61K2300/00
Inventor 朱风堂
Owner 黑龙江参鸽药业有限公司
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