Application of detection tool and detection kit taking sICAM-1 (soluble Intercellular Cell Adhesion Molecule-1) as detection index in detection of lupus nephritis

Abstract

The invention discloses application of a detection tool and a detection kit taking sICAM-1 (soluble Intercellular Cell Adhesion Molecule-1) as a detection index in detection of lupus nephritis. The lupus nephritis is lupus nephritis in an active phase, a detection sample of the lupus nephritis is urine, and the detection duration of the lupus nephritis is 10-15 minutes. The technical scheme in theinvention depends on an existing detection tool, and novel application used for detecting the lupus nephritis is developed. The detection tool and the detection kit in the invention are used for performing sampling detection on lupus nephritis patients in an active phase and in a non-active phase, patients suffering from systemic lupus erythematosus unmerged with the lupus nephritis and healthy persons. Results show that the detection kit is excellent in sensitivity and specificity and can meet clinical detection requirements. Moreover, according to the invention, the operation is simple, thetime consumption is low, the pain of the patients can be relieved and clinical popularization and application are convenient.

Description

technical field [0001] The invention relates to the field of rapid medical detection, in particular to the application of a detection tool and a detection box using sICAM-1 as a detection index in the detection of lupus nephritis. Background technique [0002] Lupus nephritis (LN) is one of the most common complications of systemic lupus erythematosus, and end-stage renal disease caused by lupus nephritis is the main factor leading to the death of patients with systemic lupus erythematosus. The main reason for developing from lupus nephritis to end-stage renal disease is that the active lupus nephritis is not detected in time, leading to untimely treatment, irreversible glomerulosclerosis and interstitial vascular fibrosis in the kidney. For the judgment of the activity of lupus nephritis, the "gold standard" is to conduct pathological examination of kidney tissue through renal biopsy, and make a diagnosis based on the pathological examination results. However, renal biopsy...

AI Technical Summary

Problems solved by technology

However, renal biopsy is an invasive examination with many contraindications and cannot be routinely performed many times. Therefore, there is currently a lack of non-invasive, accurate, fast and safe detection tools in clinical practice.

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