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Device for on-line detection of particle properties in fluidized bed granulation process

A technology of fluidized bed granulation and detection equipment, which is applied in the direction of measuring equipment, particle and sedimentation analysis, specific gravity measurement, etc. It can solve the problems of inability to meet the requirements of industrial production on-line monitoring, affect measurement results, and cumbersome operations, etc., and achieve reduction The detection speed and the requirements for additional cleaning accessories, the effect of improving the detection environment and avoiding human errors

Active Publication Date: 2020-04-28
ZHEJIANG UNIV
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this detection device is that it can only detect the particle size distribution of the particles in the fluidized bed online, and cannot detect parameters such as angle of repose, bulk density, and tap density.
This detection method has simple equipment and low cost, but the operation is cumbersome. The properties of the particles need to be measured separately by multiple different instruments. The characteristics of the particles are also easy to change during the transfer process. The accuracy of the measurement results is not good. The degree will also affect the measurement results; at the same time, this method belongs to the offline detection method, which has a large hysteresis and cannot meet the requirements of industrial production on-line monitoring

Method used

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  • Device for on-line detection of particle properties in fluidized bed granulation process
  • Device for on-line detection of particle properties in fluidized bed granulation process
  • Device for on-line detection of particle properties in fluidized bed granulation process

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Embodiment Construction

[0036] Such as figure 1 As shown, the on-line detection device used to test the particle properties in the fluidized bed granulation process, the detection device A is installed outside the fluidized bed reaction chamber 1; the detection device A has a sealed shell and can take out samples from the reaction chamber 1 sample collection agency.

[0037] Such as figure 2 As shown, the casing is provided with a first visual detection unit that photographs the falling process of the sample taken out in the casing; the casing is equipped with a second visual detection unit that detects the bulk density and tapped density of the sample, and the sample is transferred from the sample The mechanism is transferred from the first visual detection unit to the second visual detection unit, and the image information obtained by the first visual detection unit and the second visual detection unit is input into the image processing system.

[0038] Such as figure 2 As shown, the sample co...

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Abstract

The invention provides an apparatus for on-line detection of particle properties during fluidized-bed granulation. The apparatus comprises a hermetic shell, a sample acquisition mechanism, a first visual inspection unit, a second visual inspection unit and an image processing system, wherein the first visual inspection unit comprises a first camera, a circular tray and a pressure transducer; the image processing system acquires the particle size information of particles from a falling image of a sample and acquires the angle alpha of repose from an image of a sample accumulation; the second visual inspection unit comprises a measuring cylinder, a measuring-cylinder fixing plate, a light source, a vibrating table and a second camera; and the image processing system acquires the apparent density rho of the particles from the image of the sample in the measuring cylinder before starting of the vibrating table and acquires the tap density rho<t> of the particles from the image of the sample in the measuring cylinder during vibration of the vibrating table. The apparatus provided by the invention can realize on-line detection of the particle size distribution, repose angle, apparentdensity, tap density, porosity and Hausner ratio of the particles during fluidized-bed granulation.

Description

technical field [0001] A device for on-line detection of particle properties during fluidized bed granulation. Background technique [0002] The granulation fluidized bed completes granulation, coating and drying in one step in the pharmaceutical process, and is widely used in the pharmaceutical production process. [0003] The particle diameter range produced by the fluidized bed not only affects the next step of the process, but also affects the quality of the final drug. The operating parameters of the existing granulation fluidized bed are fixed during production, and the batches and environment of raw materials will change with time, and the operating parameters cannot be changed with these changes, which will result in poor quality consistency of the obtained drugs , even fails. Real-time online detection of particle diameter can change the operating parameters according to these changes, so that the particle diameter distribution is within the expected range, not on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N15/02G01N15/08G01N9/00G01N15/00
CPCG01N9/00G01N15/00G01N15/0227G01N15/088
Inventor 瞿海斌赵洁魏燕定田埂方升
Owner ZHEJIANG UNIV
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