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Application of SCAD gene or SCAD protein in preparation of medicines for prevention and treatment of vascular remodeling and serious vascular diseases

A vascular remodeling, 1.SCAD technology, applied in the field of biomedicine, can solve the problems of elevated blood pressure, aggravated vascular remodeling, etc.

Inactive Publication Date: 2018-04-06
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing antihypertensive drugs only stay at the level of lowering blood pressure, and do not directly improve the level of vascular remodeling. However, vascular remodeling in hypertension and entering a vicious cycle will further increase blood pressure, and vascular remodeling will further increase. aggravate

Method used

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  • Application of SCAD gene or SCAD protein in preparation of medicines for prevention and treatment of vascular remodeling and serious vascular diseases
  • Application of SCAD gene or SCAD protein in preparation of medicines for prevention and treatment of vascular remodeling and serious vascular diseases
  • Application of SCAD gene or SCAD protein in preparation of medicines for prevention and treatment of vascular remodeling and serious vascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Spontaneously hypertensive rats of different ages are in a stable period of hypertension

[0047] 1. In this example, changes in systolic blood pressure of spontaneously hypertensive rats aged 16, 18, 20, 22, and 24 weeks were tested.

[0048] 2. The result is as follows figure 1 As shown, spontaneously hypertensive rats of different ages were in the stable period of hypertension. After 8 weeks of swimming training, the blood pressure of the swimming group of spontaneously hypertensive rats was significantly lower, indicating that swimming training has a certain effect on improving hypertension.

Embodiment 2

[0049] Example 2 Changes in Morphology of Rat Aorta in Each Group

[0050] 1. In this embodiment, the changes in the morphology of the aorta of rats in each group were tested.

[0051] 2, figure 2 HE staining results of aorta of rats in each group. figure 2 A represents the thickness of the vascular media, figure 2 B represents the diameter of the vessel lumen, figure 2 C represents the ratio of the thickness of the vessel media to the diameter of the lumen. The result is as figure 2 As shown, the thickness of the vascular media in spontaneously hypertensive rats was significantly increased, the diameter of the vascular lumen was significantly reduced, the ratio of the vascular media thickness to the vascular cavity was significantly increased, and the arrangement of vascular fibers was disordered, with unclear layers and fractures. Membrane hyperplasia and shedding were obvious, the smoothness of vascular intima decreased significantly, and obvious vascular remodeli...

Embodiment 3

[0052] Example 3 Changes in mRNA, protein levels and SCAD enzyme activity of rat aorta SCAD in each group

[0053] 1. In this embodiment, the changes of mRNA, protein levels and SCAD enzyme activity of rat aorta SCAD in each group were tested.

[0054] 2, image 3 A represents the change of SCAD enzyme activity, image 3 B represents the change of SCAD mRNA level, image 3 C represents changes in SCAD protein levels. The result is as image 3 As shown, the expressions of SCAD mRNA and protein in the aorta of the exercise group rats were significantly up-regulated, and the activity of SCAD enzyme increased; while the expressions of SCAD mRNA and protein in the aorta of the SHR group were significantly down-regulated, and the activity of SCAD enzyme decreased. In addition, after SHR was trained by swimming for 8 weeks, the expression of SCAD mRNA and protein in the aorta were significantly up-regulated, and the activity of SCAD enzyme was increased.

[0055] The experimenta...

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Abstract

The invention discloses an application of a SCAD gene or a SCAD protein in vascular remodeling and particularly discloses applications of the SCAD gene, the SCAD protein or an expression accelerator or an activator of the SCAD protein in preparation of medicines for prevention and treatment of vascular remodeling and serious vascular diseases. By means of construction of an animal model, the invention, for the first time, discloses the important effects of the SACD in hypertension vascular remodeling, and provides a theoretical basis and an available evidence for development of novel medicinesfor the vascular remodeling and related serious vascular diseases. The SCAD gene and the SCAD protein are used for novel medicine action targets of the vascular remodeling and related serious vascular diseases.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and more specifically, the invention relates to the application of SCAD gene or protein in the preparation of medicines for preventing and treating vascular remodeling, and the application in the preparation of medicines for preventing and treating major vascular diseases. Background technique [0002] Hypertension is one of the common cardiovascular diseases that seriously endanger human health. Hypertension can cause changes in vascular structure and function, that is, hypertensive vascular remodeling, which can promote the progression of hypertension and increase cardiovascular disability and mortality. The occurrence of major vascular diseases is closely related to vascular remodeling in hypertension. [0003] Vascular remodeling has long been attributed as a secondary complication of hypertension and other cardiovascular diseases. However, the latest research results show that vascular ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6876C12Q1/32C12Q1/66A61K48/00A61K45/00A61K38/44A61P9/00
CPCA61K38/443A61K45/00A61K48/005C12Q1/32C12Q1/66C12Q1/6876C12Q2600/106
Inventor 周四桂徐立朋李忠洪
Owner GUANGDONG PHARMA UNIV