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A kind of manufacturing method of 3D printing artificial bone

A 3D printing and artificial bone technology, which is applied in the medical field, can solve the problems such as the inability to achieve personalized combined medicine for different patients, and the inability of bone cement to effectively carry sustained-release drugs, and achieve the effect of improving the technical effect.

Active Publication Date: 2020-12-11
PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The embodiment of the present application provides a manufacturing method of 3D printed artificial bone, which solves the technical problem that the bone cement in the prior art cannot effectively carry sustained-release drugs, and cannot achieve personalized drug combination for different patients. Orthopedic surgery needs to carry a variety of different drugs at the same time, to achieve the technical effect of simultaneous release of multiple drugs and combined medication

Method used

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  • A kind of manufacturing method of 3D printing artificial bone
  • A kind of manufacturing method of 3D printing artificial bone
  • A kind of manufacturing method of 3D printing artificial bone

Examples

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Embodiment 1

[0030] figure 1 It is a schematic flowchart of a manufacturing method of 3D printing artificial bone provided in the embodiment of the present application. Such as figure 1 As shown, the method includes:

[0031] Step 110: Obtain the first sensitive drug;

[0032] Specifically, the sensitive drug refers to the drug required for long-term sustained-release treatment of the target object during the treatment of osteomyelitis. Among them, according to the level of drug sensitivity, it can be divided into the first sensitive drug, the second sensitive drug, the third sensitive drug, the fourth sensitive drug, etc., wherein, according to the degree of sensitivity to the target object, it can be defined as : the sensitivity of the first sensitive drug is lower than that of the second sensitive drug, the sensitivity of the second sensitive drug is lower than that of the third sensitive drug, and the sensitivity of the third sensitive drug is lower than that of the second sensitive...

Embodiment 2

[0049] In order to realize the use of more sensitive drugs and further improve the sustained-release effect, the embodiment of the present application also provides a manufacturing method of 3D printing artificial bone, such as figure 2 As shown, the method includes:

[0050] Step 210: Obtain the third sensitive drug;

[0051] Step 220: Obtain a fourth sensitive drug, wherein the sensitivity of the second sensitive drug is lower than that of the third sensitive drug, and the sensitivity of the third sensitive drug is lower than that of the fourth sensitive drug drug;

[0052] Specifically, step 210 and step 220 can refer to the explanation of step 110 and step 120, the sensitivity of the second sensitive drug is lower than that of the third sensitive drug, and the sensitivity of the third sensitive drug Lower than the fourth sensitive drug.

[0053] Step 230: Dissolving the third sensitive drug in the solvent to make a third suspension;

[0054] Step 240: configuring the ...

Embodiment 3

[0062] In order to realize the use of more sensitive drugs and further improve the sustained-release effect, the embodiment of the present application also provides a manufacturing method of 3D printing artificial bone, such as image 3 As shown, the method includes:

[0063] Step 310: Obtain a fifth sensitive drug, wherein the sensitivity of the fifth sensitive drug is higher than that of the first sensitive drug;

[0064] Step 320: dissolving the fifth sensitive drug in the solvent, and making a fifth suspension;

[0065] Step 330: After adding the first solid substance into the fifth suspension, add the calcium-containing compound with a weight percentage of 5%-50% to form a third solid substance.

[0066] Step 340: Obtain a sixth sensitive drug, wherein the sensitivity of the sixth sensitive drug is higher than that of the fifth sensitive drug;

[0067] Step 350: Dissolving the sixth sensitive drug in the solvent to make a sixth suspension;

[0068] Step 360: After addi...

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Abstract

Embodiments of the invention provide a manufacturing method for 3D-printed artificial bone, belonging to the field of medical technology. The manufacturing method comprises the following steps: acquiring a first sensitive medicine; acquiring a second sensitive medicine; dissolving chitosan with weight percentage of 1 to 90 wt% in double-distilled water to obtain a solvent; dissolving the first sensitive medicine in the solvent and preparing a first suspension; adding a calcium-containing compound with weight percentage of 5 to 50% into the first suspension to prepare a first solid; dissolvingthe second sensitive medicine in the solvent and preparing a second suspension; adding the first solid into the second suspension, and then adding a calcium-containing compound with weight percentageof 0.5 to 30% to prepare a first paste material; and adding the first paste material into a biological 3D printer for printing so as to form the first artificial bone. In a medicine-containing paste material for the artificial bone, the medicine-containing solid is prepared from chitosan and double-distilled water, so a plurality of medicines are released at the same time; and drug effect is improved due to combined usage of the medicines.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for manufacturing 3D printed artificial bones. Background technique [0002] Osteomyelitis is an infection and destruction of bone caused by aerobic or anaerobic bacteria, mycobacteria and fungi. In the treatment of osteomyelitis, it is often necessary to penetrate the bone injury site and fill it with bone cement and other substances. [0003] However, in the process of realizing the technical solution of the invention in the embodiment of the present application, the inventor of the present application found that the above-mentioned technology has at least the following technical problems: [0004] In the prior art, in the clinical treatment of osteomyelitis, bone cement is used as a carrier or support to use slow-release drugs. However, the above solution cannot be absorbed by the body because the bone cement does not have degradability and biocompatibility. At the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C64/00A61L27/54A61L27/20A61L27/40A61L27/18A61L27/50A61L27/12B82Y30/00B82Y40/00
CPCA61L27/12A61L27/18A61L27/20A61L27/50A61L27/54A61L2300/404A61L2300/602A61L2430/02B33Y10/00C08L5/08C08L67/04
Inventor 李征宇曾庆丰
Owner PARTICLE CLOUD BIOTECHNOLOGY (HANGZHOU) CO LTD
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