Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them

A composition and technology of fecal microorganisms, applied in the field of preparations, non-specific abdominal pain, can solve problems such as limitations

Active Publication Date: 2018-04-20
CRESTOVO HLDG LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of such treatments is limited by the logistics of obt

Method used

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  • Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them
  • Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them
  • Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0302] Embodiment 1: A pharmaceutical composition comprising a fecal microbiota preparation in a lyophilized formulation, wherein after storage at ambient temperature or lower for at least 12 weeks, relative to at the beginning of said storage The initial cell viability of the fecal microbiota preparation is capable of maintaining at least 60% of the cell viability.

Embodiment approach 2

[0303] Embodiment 2: The pharmaceutical composition of Embodiment 1, wherein after storage at ambient temperature or lower for at least 12 weeks, the fecal microbiota preparation is capable of maintaining about 60 % to about 80% cell viability.

Embodiment approach 3

[0304] Embodiment 3: The pharmaceutical composition of Embodiment 1 or 2, wherein the lyophilized fecal microbiota preparation comprises a non-selected and substantially intact fecal microbiota preparation from a single donor.

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PUM

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Abstract

This application provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments, and methods for making, storing and using them, including storage, including long term storage, at ambient temperature. Compositions provided herein are useful for treating various diseases or conditions such as autism spectrum disordor, Crohn's Disease, ulcerative colitis, irritable bowel syndrome, and recurrent or primary C.difficile infection.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to US Provisional Patent Application No. 62 / 161,826, filed May 14, 2015, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates generally to medicine as well as gastroenterology, pharmacology and microbiology. In alternative embodiments, there is provided for gastric, gastrointestinal and / or colonic therapy or lavage, e.g., orthostatic lavage, e.g., for inducing decontamination (e.g. cleansing) of the gastrointestinal (GI) tract including the colon Compositions, such as formulations; and methods for making, storing and using them, including storage, including long-term storage. In alternative embodiments, the compositions provided herein are used for stabilizing, ameliorating, treating and / or preventing constipation, for treating abdominal pain, especially non-specific abdominal pain; and diarrhea, including side e...

Claims

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Application Information

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IPC IPC(8): A61K35/38C07K14/195A61P31/04A61P25/00A61P1/00A61P1/04
CPCA61K35/74A61K35/24A61K9/0053A61K9/19A61K47/26A61P31/04A61P25/00A61P1/00A61P1/04A61K47/10A61K9/4858A61K35/742A61K35/747A61K35/745A61P31/00Y02A50/30A61K9/48A61K47/36A61K9/4866
Inventor T·J·鲍罗迪
Owner CRESTOVO HLDG LLC
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