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Flexible glucose electrochemical sensor

A glucose and electrochemical technology, applied in the direction of material electrochemical variables, can solve the problems of high production cost, complex process, and low scale, and achieve good mass production, simple preparation process, and excellent electrical conductivity.

Inactive Publication Date: 2018-05-15
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the cost of sensor materials made by these methods is high, the process is complicated, and the degree of scale is low, which makes the production cost of such products high and expensive, which restricts the popularization and application of CGMS systems.
[0005] At present, the industrial blood glucose meter adopts the method of laboratory measurement after acupuncture blood collection. Although this measurement method is more accurate, it will cause some pain to the patient, and this method is intermittent to the measurement of blood sugar. The data can only provide the concentration of blood sugar at the time of measurement, and cannot give accurate guidance on the dosage of insulin each time
It is very important to continuously measure the concentration of glucose in the body. The current glucose sensor cannot be applied to the clinic. Continuously measuring the concentration of glucose in the system is one of the problems that researchers are currently facing. One of the main reasons is its rigidity. The structure makes the biocompatibility of the glucose sensor poor, so it is of great significance to construct a flexible electrochemical biosensor for glucose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The ITO glass is self-assembled in 6 layers, and the ITO glass needs to be cleaned before assembly. The cleaning process is to ultrasonically clean the ITO glass with deionized water, acetone and ethanol for 30 minutes, respectively. After cleaning, put it into an ozone cleaner for surface hydroxylation. Then the ITO glass was self-assembled layer by layer in PDDA (polydiallyl dimethyl ammonium chloride) and PSS (polystyrene sodium sulfonate) solutions.

[0027] Deposit dendritic nano-silver on the assembled ITO glass, the method adopted is chronoamperometry, the reference electrode is a saturated mercurous sulfate electrode, the counter electrode is a platinum wire, the working electrode is an assembled ITO glass, and the electrolyte is AgNO 3 and NaNO 3 Mixed solution, deposition time 400s, AgNO 3 The concentration is 0.008mol / L, NaNO 3 The concentration is 0.1mol / L, and the set potential is -0.3V. Through electrochemical deposition, a white nano-silver conducti...

Embodiment 2

[0030] 6-layer self-assembly of ITO glass. ITO glass needs to be cleaned before assembly. The cleaning process is to ultrasonically clean the ITO glass with deionized water, acetone and ethanol for 30 minutes, respectively. After cleaning, put it into an ozone cleaner for surface hydroxylation. Then the ITO glass was self-assembled layer by layer in PDDA and PSS solution.

[0031] Deposit dendritic nano-silver on the assembled ITO glass, the method adopted is chronoamperometry, the reference electrode is a saturated mercurous sulfate electrode, the counter electrode is a platinum wire, the working electrode is an assembled ITO glass, and the electrolyte is AgNO 3 and NaNO 3 Mixed solution, deposition time 700s, AgNO 3 The concentration is 0.008mol / L, NaNO 3 The concentration is 0.1mol / L, and the set potential is -0.3V.

[0032] Put the silver-deposited ITO glass into the PDMS solution and put it into an oven for curing. The curing temperature is 70° C. and the curing ti...

Embodiment 3

[0034] 6-layer self-assembly of ITO glass. ITO glass needs to be cleaned before assembly. The cleaning process is to ultrasonically clean the ITO glass with deionized water, acetone and ethanol for 30 minutes, respectively. After cleaning, put it into an ozone cleaner for surface hydroxylation. Then the ITO glass was self-assembled layer by layer in PDDA and PSS solution.

[0035] Deposit dendritic nano-silver on the assembled ITO glass, the method adopted is chronoamperometry, the reference electrode is a saturated mercurous sulfate electrode, the counter electrode is a platinum wire, the working electrode is the previously assembled ITO glass, and the electrolyte is AgNO 3 and NaNO 3Mixed solution, deposition time 800s, AgNO 3 The concentration is 0.008mol / L, NaNO 3 The concentration is 0.1mol / L, and the set potential is -0.3V.

[0036] Put the silver-deposited ITO glass into the PDMS solution and put it into an oven for curing. The curing temperature is 70° C. and th...

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Abstract

The divisional application discloses a flexible glucose electrochemical sensor, belonging to the technical field of electrochemical sensors. A flexible electrode substrate is polydimethylsiloxane (PDMS), and a dendritic structure nano-silver conducting layer is arranged on the PDMS substrate. The preparation method comprises the steps of carrying out self-assembly of indium tin oxide (ITO) glass,carrying out electrochemical deposition of a dendritic structure nano-silver film layer on the ITO glass, putting the ITO glass with the nano-silver conducting layer into a PDMS solution for curing, and then removing the PDMS film from the ITO glass to obtain the flexible glucose electrochemical sensor based on a dendritic nano-silver structure. The flexible glucose electrochemical sensor providedby the invention has a good response to glucose, is simple in preparation method and is easy to mass production, thus being expected to be widely applied to industrial and agricultural production aswell as life science research, especially wearable medical equipment field.

Description

[0001] The present invention is a divisional application with the application number 2017107651280, the application date of August 30, 2017, and the title of the invention "a flexible glucose electrochemical sensor based on a dendritic nano-silver structure". technical field [0002] The invention relates to the field of electrochemical sensors, in particular to a flexible glucose electrochemical sensor based on a dendritic nano-silver structure. Background technique [0003] Glucose is the most important substance in living organisms. Glucose metabolism is the most basic energy conversion pathway in organisms and the cornerstone of normal metabolism, growth and development of organisms. Glucose metabolism in animals will be affected by blood sugar concentration and insulin content. When blood sugar concentration is too high or insulin is lacking in the body, glucose metabolism disorder will occur and cause diabetes. Wide fluctuations in blood sugar lead to chronic complica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/36G01N27/48
CPCG01N27/36G01N27/48
Inventor 孙晶李秀平郎明非王迪周文慧罗才辉罗来福
Owner DALIAN UNIV
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