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Application of syringin in drug combination for treating tumors

A technology for combining medication and syringin, which is applied in the field of biomedicine to achieve the effects of reducing toxic side effects, having good application prospects and enhancing anti-tumor effects.

Inactive Publication Date: 2018-05-29
陕西医药控股集团新药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no literature report on the combined use of syringin and chemical antineoplastic drugs in the treatment of tumors

Method used

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  • Application of syringin in drug combination for treating tumors
  • Application of syringin in drug combination for treating tumors
  • Application of syringin in drug combination for treating tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Cell lines and culture conditions

[0020] Human hepatoma cell line HepG2 was purchased from the China Center for Type Culture Collection, and was fully cultured in MEM at 37°C, 5% CO 2 Cultured in an incubator.

[0021] 2. Drugs

[0022] Syringin, provided by Shaanxi Institute of Traditional Chinese Medicine; fluorouracil injection, Shanghai Xudong Haipu Pharmaceutical Co., Ltd. (batch number FA161208);

[0023] Divide the cell lines into groups: negative control group and drug experimental group

[0024] 1) Negative control group: given the same amount of solvent dimethyl sulfoxide (DMSO) as the drug experimental group.

[0025] 2) drug experiment group

[0026] Drug group 1: 10 μg / mL of syringin was administered.

[0027] Drug group 2: 20 μg / mL of syringin was administered.

[0028] Drug group 3: 40 μg / mL of syringin was administered.

[0029] Drug group 4: 80 μg / mL of syringin was administered.

[0030] Drug group 5: 0.63 μg / mL of fluorouracil was given. ...

Embodiment 2

[0068] 1. Cell lines and culture conditions

[0069] Human prostate cancer cell line PC-3 was purchased from the China Center for Type Culture Collection, and was fully cultured in MEM at 37°C, 5% CO 2 Cultured in an incubator.

[0070] 2. Drugs

[0071] Syringin, provided by Shaanxi Institute of Traditional Chinese Medicine; fluorouracil injection, Shanghai Xudong Haipu Pharmaceutical Co., Ltd. (batch number FA161208);

[0072] Divide the cell lines into groups: negative control group and drug experimental group

[0073] 1) Negative control group: given the same amount of solvent dimethyl sulfoxide (DMSO) as the drug experimental group.

[0074] 2) drug experiment group

[0075] Drug group 1: 10 μg / mL of syringin was administered.

[0076] Drug group 2: 20 μg / mL of syringin was administered.

[0077] Drug group 3: 40 μg / mL of syringin was administered.

[0078] Drug group 4: 80 μg / mL of syringin was administered.

[0079] Drug group 5: 0.63 μg / mL of fluorouracil was g...

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Abstract

The invention discloses an application of syringin in a drug combination for treating tumors. The drug combination is prepared from the syringin and a chemical anti-tumor drug. An in-vitro study discovers that after the chemical anti-tumor drug and the syringin are combined for medication, the curative effect is remarkably enhanced.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the combined drug treatment use of syringin in preventing and treating tumors. Background technique [0002] With the development of medicine and the advancement of science and technology, various infectious diseases and common diseases have been gradually controlled by people. However, due to its strong concealment, long incubation period, and high mortality, malignant tumors have become the second largest killer of humans in terms of mortality after cardiovascular diseases. Cancer has become a common disease that seriously threatens human health, and there is no targeted specific drug. With the continuous development of molecular biology theory and in-depth research in recent years, it has become a topic of concern and a difficult problem in the medical field to actively seek effective anti-tumor drugs and prevention methods for cancer treatment. Since the use of chemical...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61K31/513A61P35/00
CPCA61K31/7034A61K31/513A61K2300/00
Inventor 秦湫红肖志强
Owner 陕西医药控股集团新药技术开发有限公司
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