Inflammation-antagonistic agent containing lysophosphatidic acid

A technology of lysophosphatidic acid and an inflammatory agent, which is applied in the field of inflammatory antagonism, can solve the problems of obvious side effects, increase the chance of infection, and reduce the efficacy of the drug, and achieve the effects of obvious drug efficacy, significant therapeutic effect, and rapid and effective disease control.

Inactive Publication Date: 2018-06-01
GUANGDONG YIMING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, the variety of drugs for allergic inflammation is relatively single, and it is not very convenient to use. One drug can only target one link, which is not enough to completely and effectively control the disease
In most cases, two or more anti-allergic preparations need to be used in combination at the same time to be effective, which is very inconvenient to use and carry
A single drug is usually used for a long time, the drug effect is reduced, and the side effects are obvious. Even if it is used in combination, the chance of infection will increase after a long time, and it is prone to bacterial conjunctivitis, and the treatment effect is unstable.

Method used

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Embodiment Construction

[0011] In order to make the technical means, creative features, achievement goals and effects realized by the present invention easy to understand, the present invention will be further described below with reference to the specific embodiments.

[0012] The invention provides a technical scheme: an inflammatory agent containing lysophosphatidic acid, which is composed of the following raw materials: sorbitol, hypromellose, glycine, polyethylene glycol, zinc oxide, glycerin, gentamicin , Azelastine, Lysophosphatidic acid.

[0013] The zinc ingot prepared by electrolysis is heated to 600~700℃ and melted, then placed in a high temperature resistant crucible to melt and gasify at a high temperature of 1250~1300℃, and then introduce hot air for oxidation. The zinc oxide is cooled and cyclone separated. , the fine particles are trapped with a cloth bag, that is, the zinc oxide in the raw material is obtained.

[0014] Add the prepared 53% aqueous glucose solution to the autoclave,...

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PUM

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Abstract

The invention provides an inflammation-antagonistic agent containing lysophosphatidic acid. The inflammation-antagonistic agent is prepared from the following raw materials: sorbitol, hydroxypropyl methylcellulose, glycine, polyethylene glycol, zinc oxide, glycerinum, gentamicin, azelastine and lysophosphatidic acid. Compared with the prior art, the inflammation-antagonistic agent provided by theinvention has the following beneficial effects that multiple drugs are integrated to play a synergistic role, so that the drug effect is obvious, the disease control is rapid and effective, not only can the treating effect for skin inflammations be obvious, but also no pain is caused to a patient; simultaneously, no layering is caused in storage, and no agglomeration is caused at the bottom of a container.

Description

technical field [0001] The invention relates to an inflammatory antagonist containing lysophosphatidic acid, belonging to the field of pharmaceuticals. Background technique [0002] Lysophosphatidic acid (1-acyl-2-hydroxy-sn-glycerol-3-phosphate, LPA) is a biologically derived membrane lipid through the action of several enzymatic reactions involving phospholipase A2 and lysophospholipase D. Active lipid mediator. LPA plays a role in several cellular functions such as: cell proliferation, differentiation, survival, migration and invasion. These functions affect many physiological and pathological processes including angiogenesis, wound repair, fibrosis, inflammation and carcinogenesis. [0003] In the prior art, the variety of medicines for allergic inflammation is relatively simple, and it is not very convenient to use. One medicine can only target one link, which is not enough to completely and effectively control the disease. In most cases, two or more anti-allergic pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K31/55A61K31/661A61K47/02A61K47/10A61K47/18A61K47/38A61P29/00A61P17/00
CPCA61K31/55A61K31/661A61K31/7036A61K47/02A61K47/10A61K47/183A61K47/38A61K2300/00
Inventor 李易春
Owner GUANGDONG YIMING PHARMA
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