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A method for reciprocating transport of micro-droplets

A micro-droplet and chip technology, applied in chemical instruments and methods, laboratory utensils, fluid controllers, etc., can solve problems such as high cost, complex processing technology, and disordered droplet environment, and achieve low cost and controllable distance. , the effect of simple device structure

Inactive Publication Date: 2021-05-11
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are many shortcomings in the micro-droplet transport methods reported so far, such as: the need to prepare micro-channels, micro-chambers and other devices, high cost and complicated processing technology; the direction and distance of micro-droplet transport are uncontrollable; The long-term irradiation of the droplet will cause the internal environment of the droplet to be disordered; the environment of the micro-droplet is limited; the reciprocating transport of the micro-droplet cannot be realized; the transport process cannot be controlled in real time, etc.

Method used

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  • A method for reciprocating transport of micro-droplets
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  • A method for reciprocating transport of micro-droplets

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Effect test

Embodiment 1

[0029] Using a 473nm laser, the laser power is 10mW, the background light source is a halogen lamp, the magnification of the focusing objective lens is 16 times, and the micro-droplet with a volume of 0.05μL to be transported is introduced into the lithium niobate sandwich structure chip, and the intelligent digital display temperature is used. The controller heats the semiconductor cooling sheet. When the temperature of the temperature controller panel shows 30.23°C, keep it warm for 5 minutes, open the electronic shutter, move the transparent fine-tuning three-dimensional translation stage, and make the laser spot sweep a line on the lithium niobate sandwich structure chip. A straight line with a length of 0.70mm is close to the micro-droplet. When the micro-droplet is attracted to the laser spot, the electronic shutter is closed to complete the reciprocating transport of the micro-droplet.

Embodiment 2

[0031] Using a 532nm laser, the laser power is 15mW, the background light source is a halogen lamp, and the magnification of the focusing objective lens is 16 times. The micro-droplet with a volume of 0.07μL to be transported is introduced into the lithium niobate sandwich structure chip, and the intelligent digital display temperature is used. The controller heats the semiconductor cooling sheet. When the temperature of the temperature controller panel shows 33.45°C, keep it warm for 5 minutes, open the electronic shutter, move the transparent fine-tuning three-dimensional translation stage, and make the laser spot sweep a line on the lithium niobate sandwich structure chip. A straight line with a length of 0.25mm is close to the micro-droplet. When the micro-droplet is attracted to the laser spot, the electronic shutter is closed to complete the reciprocating transport of the micro-droplet.

Embodiment 3

[0033] Using a 405nm laser, the laser power is 18mW, the background light source is a halogen lamp, the magnification of the focusing objective lens is 16 times, and the micro-droplet with a volume of 0.08 μL to be transported is introduced into the lithium niobate sandwich structure chip, and the intelligent digital temperature display is used. The controller heats the semiconductor cooling chip. When the temperature controller panel temperature shows 38.65°C, keep it warm for 5 minutes, open the electronic shutter, move the transparent fine-tuning three-dimensional translation stage, and make the laser spot sweep a line on the lithium niobate sandwich structure chip. A straight line with a length of 0.30mm is close to the micro-droplet. When the micro-droplet is attracted to the laser spot, the electronic shutter is closed to complete the reciprocating transport of the micro-droplet.

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Abstract

The invention discloses a reciprocating transportation method of micro-droplets, which uses a lithium niobate interlayer structure chip as a base, heats up the chip through a heating system, and controls the laser spot to sweep a straight line in any direction on the chip surface and approach the micro-droplets in the chip. When the droplet is attracted to the laser spot, the electronic shutter is closed, and the reciprocating transport of the droplet is realized under the combined action of thermal effect and photovoltaic effect. The method has the characteristics of controllable droplet transportation direction and distance, no direct contact between laser and droplet, and the whole process can be observed in real time. This technology can be applied to the collection, mixing and transportation of trace reagents, and is of great significance to the development of biomedicine, drug diagnosis, environmental monitoring and molecular biology.

Description

technical field [0001] The invention relates to a micro-droplet manipulation technology, in particular to a micro-droplet reciprocating transport method Background technique [0002] With the rapid development of microfluidic chips, micro-droplet manipulation has become a research hotspot in this field. Micro-droplet manipulation technology is mainly used in the analysis and detection of micro-sample in biological, chemical, pharmaceutical and other processes. It mainly involves the collection, mixing and transportation of micro-quantity reagents. It is of great significance to the development of fields such as biomedicine, drug diagnosis, food hygiene, environmental monitoring and molecular biology. [0003] 2003 document (Monolithic membrane valves and diaphragm pumps for practical large-scale integration into glass microfluidic devices, Sens.ActuatorsB, 89, 315-323 (2003)) reported a method of utilizing a micro air pump device to complete micro liquid transport, the The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L3/502784B01L2400/0415B01L2400/0424
Inventor 阎文博李菲菲樊博麟王旭亮李少北昝知韬梁超陈洪建
Owner HEBEI UNIV OF TECH
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