A degradable absorbable hemostatic material containing modified starch nanoparticles and its application

A technology of modified starch and hemostatic materials, which is applied in the field of medical devices, can solve the problems of difficult to clean excess hemostatic materials, non-dense gel structure, and poor gel adhesion, so as to achieve no allergic reaction and good biocompatibility , strong water absorption effect

Active Publication Date: 2020-12-08
张家港唯瀚生物科技有限公司
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  • Claims
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AI Technical Summary

Problems solved by technology

The gel structure formed by the existing hemostatic materials is not dense, resulting in bleeding and exudation; the solubility is poor, it is difficult to clean up the excess hemostatic materials during the operation, and the degradation is slow after the operation; the gel formed by the wound tissue has poor adhesion, etc.

Method used

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  • A degradable absorbable hemostatic material containing modified starch nanoparticles and its application

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Embodiment Construction

[0014] 1. Dissolve 5g of cross-linked carboxymethyl starch sodium with a sodium content of 4% in 100ml of purified water, and keep stirring to disperse the cross-linked carboxymethyl starch sodium evenly in the water. Homogenize under high pressure (50, 100, 150, 200 MPa each for 1 min to obtain cross-linked sodium carboxymethyl starch nanoparticle solution, pour it into a container, freeze-dry at -40°C, vacuum degree less than 40 Pa for 48 hours, and then crush to obtain cross-linked Sodium carboxymethyl starch nanoparticles; cross-linked sodium carboxymethyl starch particles and cross-linked sodium carboxymethyl starch nanoparticles were mixed with volume concentration 75% ethanol in a ratio of 1g: 2mL, fully stirred, centrifuged, and repeated the above Process 3 times, vacuum drying to remove ethanol; cross-linked sodium carboxymethyl starch particles and cross-linked sodium carboxymethyl starch nanoparticles are mixed in a weight ratio of 9:1, sub-packaged, and irradiated b...

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Abstract

The invention discloses a degradable absorbable hemostatic material containing modified starch nanoparticles and application thereof. The modified starch nanoparticles are obtained by nanocrystallization of modified starch serving as a raw material, and then by adopting a dry powder blending method, modified starch microparticles and the modified starch nanoparticles are mixed according to a certain ratio to obtain the degradable absorbable hemostatic material. The hemostatic material prepared by means of the method has high biocompatibility and hygroscopicity and can be directly applied to various complicated bleeding wounds to form a blood coagulation mixture with a compact structure, the blood coagulation mixture has good adhesion, a better sealing effect is achieved on the bleeding wounds, tissue healing is promoted, the hemostatic material is more easily dissolved in water, the redundant hemostatic material is more easily removed by using normal saline after hemostasis, and the material can be degraded and absorbed in vivo. The degradable absorbable hemostatic material can be used for the bleeding wounds of the human body surface, in-vivo tissues and organs and tissues or organs in the body cavity and can also be used for hemostasis in surgery and wound emergency.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a degradable absorbable hemostatic material containing denatured starch nanoparticles. Background technique [0002] Wound bleeding is a common problem in surgical operations. If it cannot be controlled in time, it may lead to hemorrhagic shock and even endanger life and health. In addition, postoperative bleeding will lead to the accumulation of interstitial fluid, which will lead to serious complications. Therefore, rapid, effective and comprehensive hemostatic materials and methods are the key to the success of surgical operations, and are also research hotspots in the medical field. [0003] With the development of polymer materials, many types of hemostatic materials have been developed. Ideal hemostatic materials should have good biocompatibility, short hemostatic time, complete hemostasis, prevent inter-tissue adhesion, and promote wound tissue repair and healing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08
CPCA61L24/001A61L24/0042A61L24/08A61L2400/04A61L2400/12C08L3/08
Inventor 吕国军陈立耿少特
Owner 张家港唯瀚生物科技有限公司
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