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Isoflavone compound with two alcoholic hydroxyl groups and its preparation method and application

A technology of compound and isoflavone, which is applied in the field of new isoflavone compound and its preparation in Fig.

Inactive Publication Date: 2020-04-24
HAINAN NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is still a lack of more systematic research on the isoflavone components of Ficus grandis, and further research on its antitumor activity is still needed

Method used

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  • Isoflavone compound with two alcoholic hydroxyl groups and its preparation method and application
  • Isoflavone compound with two alcoholic hydroxyl groups and its preparation method and application
  • Isoflavone compound with two alcoholic hydroxyl groups and its preparation method and application

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Embodiment ）

[0026] The structural formula of the isoflavone compounds of this embodiment is shown in formula (I):

[0027]

[0028] (I).

[0029] The preparation method of this isoflavone compound comprises the following steps:

[0030] ①Crush and sieve 20kg of naturally-dried Ficus ficus roots, soak and extract with ethanol with a volume fraction of 95% at room temperature for 3 times, each time for 6 days, concentrate and recover ethanol under reduced pressure to obtain 460g of total extract, add an equal volume of Suspend the extract in distilled water, first extract 3 times with 3L petroleum ether to obtain 175g of petroleum ether extract, and then use 3L ethyl acetate to extract repeatedly until the color of the upper solution becomes obviously lighter to obtain 70g of ethyl acetate.

[0031] ②Elute 70 g of the ethyl acetate fraction in step ① with petroleum ether-ethyl acetate (100:0-0:100, V / V) gradient elution, collect fractions per 500 mL, detect on TCL plate, and combine sim...

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Abstract

The invention discloses a preparation method and application of novel isoflavone compound in ficus auriculata. The preparation method of the novel isoflavone compound comprises the following steps: crushing roots of the ficus auriculata, sieving, cold extracting by using an alcohol solution, decompressing, concentrating to obtain extract, adding distilled water into the extract, suspending, and extracting successively by using petroleum ether and ethyl acetate to obtain each part extract; and performing the column chromatography and high-performance liquid phase for the ethyl acetate extract,thus obtaining the novel isoflavone compound. The novel isoflavone compound extracted from the ficus auriculata has relatively good effect for inhibiting the proliferation of three tumor cells.

Description

technical field [0001] The invention relates to a natural plant extract, in particular to a novel compound of isoflavones from Ficus figii and a preparation method thereof. Background technique [0002] There are more than 1,000 species of plants of the genus Ficus in the Moraceae family, and about 120 species in my country, 98 species and 3 subspecies are recorded in "Flora of China", and 41 species are recorded in "Flora of Hainan" . Ficus plants are mainly distributed in the tropics and subtropics. In my country, they are mainly distributed in Guizhou, Yunnan in the southwest and Fujian, Guangdong, Guangxi and Hainan on the southeast coast. The genus Ficus is rich in resources, and has been widely used as medicine in the folk, and is widely used to treat diseases such as cancer, pneumonia, vitiligo, diarrhea, tonsillitis, cough, rheumatism pain, and maternal hair milk. The active ingredients of some Ficus plants have been made into various forms of drugs such as injectio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/36C07D311/40A61K31/352A61P35/00
CPCC07D311/36C07D311/40
Inventor 韩长日邵泰明宋小平陈光英李小宝
Owner HAINAN NORMAL UNIV