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Mouthwash containing lysozyme and preparation method thereof

A technology of lysozyme and mouthwash, applied in the field of oral care products, can solve the problems of the stability of mouthwash and the activity of lysozyme need to be further improved, and achieve the effects of caring for oral health, preventing oral diseases and improving stability

Active Publication Date: 2021-04-30
SHANDONG LUBEI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been some patents applying lysozyme to mouthwash, such as CN104490621A, CN107753308A, and CN107280997A. Although these products have the effect of inhibiting the growth of harmful bacteria in the oral cavity and protecting the health of the oral cavity, generally speaking, the stability and bacteriolysis of the mouthwash The maintenance of enzyme activity needs to be further improved

Method used

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  • Mouthwash containing lysozyme and preparation method thereof
  • Mouthwash containing lysozyme and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation method of the mouthwash containing lysozyme comprises: weighing 1 part of carboxymethylpachyran, 1 part of trehalose and 1 part of glycine in parts by weight, pulverizing the carboxymethylpolysaccharide, trehalose and glycine respectively, passing through 100 mesh sieve, mix, add 1 / 4 weight part of deionized water (the total weight part of deionized water is 180 parts), stir evenly, then heat up to 100°C for 2 hours, cool to obtain the first mixed solution; press Weigh 1 part of ferulic acid, 10 parts of polyethylene glycol and 12 parts of glycerin, mix, add 1 / 2 part of deionized water by weight, and add to the second part after ferulic acid, polyethylene glycol and glycerin are dissolved. In the first mixed solution, stir evenly to obtain the second mixed solution, adjust the pH of the second mixed solution to be 6.0, add the phosphate buffer saline solution with a pH of 6.0 simultaneously, stir well, then add lysozyme (the parts by weight of lysozyme ar...

Embodiment 2

[0031]The preparation method of the mouthwash containing lysozyme comprises: weighing 2 parts of carboxymethylpachyran, 2 parts of trehalose and 2 parts of glycine in parts by weight, respectively pulverizing carboxymethylpachyan, trehalose and glycine, passing through 100 mesh Sieve, mix, add 1 / 4 weight part of deionized water (the total weight part of deionized water is 200 parts), stir evenly, then heat up to 100 ° C for 2 hours, cool to obtain the first mixed solution; press The parts by weight take 1.2 parts of ferulic acid, 12 parts of polyethylene glycol and 15 parts of glycerin, mix them, add 1 / 2 part of deionized water by weight, and add them to the second part after ferulic acid, polyethylene glycol and glycerin are dissolved. In the first mixed solution, stir evenly to obtain the second mixed solution, adjust the pH of the second mixed solution to be 6.0, add the phosphate buffer saline solution with a pH of 6.0 simultaneously, stir well, then add lysozyme (the parts...

Embodiment 3

[0034] The preparation method of the mouthwash containing lysozyme comprises: taking by weight 3 parts of carboxymethylpachyran, 3 parts of trehalose and 3 parts of glycine, respectively pulverizing the carboxymethylpachyran, trehalose and glycine, passing through 100 mesh Sieve, mix, add 1 / 4 weight part of deionized water (the total weight part of deionized water is 220 parts), stir evenly, then heat up to 100 ° C for 2 hours, cool to obtain the first mixed liquid; press Parts by weight weigh 1.5 parts of ferulic acid, 15 parts of polyethylene glycol and 20 parts of glycerin, mix, add 1 / 2 part of deionized water by weight, and add to the second In the first mixed solution, stir evenly to obtain the second mixed solution, adjust the pH of the second mixed solution to be 6.0, add the phosphate buffer saline solution with a pH of 6.0 simultaneously, stir well, then add lysozyme (the parts by weight of lysozyme are 3 parts), after stirring and dissolving, put it in a water bath e...

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Abstract

The invention discloses a mouthwash containing lysozyme, which comprises the following raw materials in parts by weight: 1-3 parts of lysozyme, 1-1.5 parts of ferulic acid, 10-15 parts of polyethylene glycol, 12-20 parts of glycerin, 1-3 parts of carboxymethyl pachyrhin, 1-3 parts of trehalose, 1-3 parts of glycine, 2-4 parts of pearl powder, 2-4 parts of aloe vera gel, 0.2-0.5 parts of sodium chloride, 0.2-0 parts of sodium alginate 0.5 parts, 0.4-0.6 parts of xylitol, 0.4-0.6 parts of citric acid, 0.1-0.3 parts of mint essence and 180-220 parts of deionized water. At the same time, a preparation method of mouthwash containing lysozyme is provided, which includes: crushing, mixing; ultrasonic treatment, stirring reaction; calcining, adding lactic acid, stirring reaction; mixing, sterilizing, and filling. The invention can effectively improve the stability of the mouthwash while maintaining the activity of lysozyme.

Description

technical field [0001] The invention relates to a mouthwash. More specifically, the invention relates to a mouthwash containing lysozyme, which belongs to the technical field of oral care products. Background technique [0002] Lysozyme, also known as mureinase or N-acetyl murein hydrolase, is a biological enzyme that can hydrolyze mucopolysaccharides in pathogenic bacteria. The enzyme has antibacterial, anti-inflammatory, and antiviral effects. At present, lysozyme is widely used as a preservative in food preservation. Because lysozyme has high safety and no side effects, research on the application of lysozyme in oral care products will have a broad market prospect. [0003] Oral care products mainly include mouthwash, toothpaste, tooth powder and cleaning gel. In recent years, the demand for mouthwash has been increasing, especially small-package mouthwash that can be carried with you has become a fashion among white-collar workers. It is used to clean the mouth anytime,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/66A61K8/98A61K8/9794A61K8/73A61K8/44A61K8/60A61Q11/00A61P1/02A61P31/04
CPCA61K8/44A61K8/60A61K8/66A61K8/73A61K8/97A61K8/987A61Q11/00
Inventor 张春颖
Owner SHANDONG LUBEI PHARMA
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