The invention provides a preparation process of compound sodium azulenesulfonate teeth-cleaning gel. The preparation process comprises the following steps: preparing a solution I, preparing a solution II, preparing a solution III, preparing a solution IV, adding accessorial ingredients, and carrying out mixing. The preparation process is reasonable and reliable, the manner of preparing intermediate solutions in advance and then carrying out vacuumizing mixing is adopted, so that the prepared gel is clear and transparent in property and good in teeth-cleaning effect, and has the efficacies of resisting inflammation, resisting allergy, and promoting the regrowth of the granulation tissue, meanwhile, the gel is combined with cetylpyridinium chloride, therefore, the pathogenic bacteria of the oral cavity can be inhibited, the formation of bacterial plaque can be prevented, the gel has very good curative effects for periodontal diseases, and finally, the oral health is maintained. In addition, the gel product does not contain an abrasive, the content of a foaming agent is low, therefore, the irritation to the oral mucosa is reduced, and the protection for the periodontal part is benefited.