A combination for brushing teeth and a preparation method thereof. Provided are a convenient processing, portable, hygienic and environment-friendly toothbrush combination and a preparation method thereof. Including a toothbrush, the bristles of the toothbrush are provided with an oral cleanser, and the oral cleanser is made of the following raw materials in terms of mass percentage: 1-10% of a Chinese medicine extract composition, 3-30% of an anionic surfactant, and an amphoteric surface Active agent 2-5%, non-ionic surfactant 0-10%, polyol humectant 1-25%, viscosity modifier 0-1%, preservative 0-0.5%, sweetener 0-0.2%, essence 0~1.2%, the balance of deionized water. In the present invention, the oral cleanser is arranged on the bristles, and the product is packaged into a clean product, which is easy to carry and saves space. At the same time, it has the following advantages: clean, strong foaming power, cool and refreshing, and good stability; the liquid (cavity cleaner) does not overflow the brush head, does not separate the water, the fragrance and color are normal, and it adheres to the gap and surface of the toothbrush bristles.