Preparation process of compound sodium azulenesulfonate teeth-cleaning gel

A technology of sodium azulene sulfonate and production process, applied in the field of oral care, can solve problems such as irritation of oral mucosa and unfavorable maintenance of periodontal health, and achieve the effects of reducing irritation, reasonable and reliable production process and low content

Inactive Publication Date: 2017-07-04
江苏恩为众心生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] As people's awareness of oral health continues to increase, the types of dental cleaning products on the market are increasing. However, in order to reduce production costs, a certain amount of abrasives and foaming agents are usually added to these dental cleaning products. Although It has a certain cleaning effect on the teeth, but long-term use will stimulate the oral mucosa, which is not conducive to the maintenance of periodontal health, and the properties of these dental cleaning products are relatively ordinary

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The production process of the compound sodium azulene sulfonate dental jelly comprises the following steps:

[0017] (1) Prepare solution I: heat 70.879% by mass of purified water to 30°C, add 0.48% by mass of sodium benzoate, 0.047% by mass of cetylpyridinium chloride and 0.047% by mass of sucralose, and stir for 20 Minutes, solution I was obtained;

[0018] (2) Preparation of solution II: 0.027% by mass of sodium azulene sulfonate was dissolved in 0.4% by mass of ethanol to obtain solution II;

[0019] (3) Prepare solution III: heat 1.8% by mass of RH40 hydrogenated castor oil and 1.8% by mass of propylene glycol to melt, add 0.74% by mass of spearmint mint essence and stir evenly to obtain solution III;

[0020] (4) Preparation of solution IV: 4.5% by mass of PEG-400, 0.82% by mass of xanthan gum, and 0.82% by mass of sodium alginate were evenly stirred to obtain solution IV;

[0021] (5) Mixing of ingredients: Add 15% by mass sorbitol solution and solution IV to t...

Embodiment 2

[0023] The production process of the compound sodium azulene sulfonate dental jelly comprises the following steps:

[0024] (1) Prepare solution I: heat 68.82% by mass of purified water to 35°C, add 0.48% by mass of sodium benzoate, 0.05% by mass of cetylpyridinium chloride and 0.05% by mass of sucralose, and stir for 24 Minutes, solution I was obtained;

[0025] (2) Prepare solution II: dissolve 0.03% by mass of sodium azulene sulfonate with 0.3% by mass of ethanol to obtain solution II;

[0026] (3) Prepare solution III: heat 2.1% by mass of RH40 hydrogenated castor oil and 2.1% by mass of propylene glycol to melt, add 0.82% by mass of spearmint mint essence and stir evenly to obtain solution III;

[0027] (4) Preparation of solution IV: 5.5% by mass of PEG-400, 1% by mass of xanthan gum, and 1% by mass of sodium alginate were evenly stirred to obtain solution IV;

[0028] (5) Mixing of ingredients: Add 14.5% by mass sorbitol solution and solution IV to the vacuum pot in s...

Embodiment 3

[0030] The production process of the compound sodium azulene sulfonate dental jelly comprises the following steps:

[0031] (1) Prepare solution I: heat 70.343% by mass of purified water to 40°C, add 0.52% by mass of sodium benzoate, 0.052% by mass of cetylpyridinium chloride and 0.052% by mass of sucralose, and stir for 25 Minutes, solution I was obtained;

[0032] (2) Preparation of solution II: 0.033% by mass of sodium azulene sulfonate was dissolved in 0.6% by mass of ethanol to obtain solution II;

[0033] (3) Prepare solution III: heat 2.3% by mass of RH40 hydrogenated castor oil and 1.96% by mass of propylene glycol to melt, add 0.82% by mass of spearmint mint essence and stir evenly to obtain solution III;

[0034] (4) Preparation of solution IV: 5.4% by mass of PEG-400, 1.1% by mass of xanthan gum, and 1.1% by mass of sodium alginate were evenly stirred to obtain solution IV;

[0035] (5) Mixing of ingredients: Add 12% by mass sorbitol solution and solution IV to th...

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PUM

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Abstract

The invention provides a preparation process of compound sodium azulenesulfonate teeth-cleaning gel. The preparation process comprises the following steps: preparing a solution I, preparing a solution II, preparing a solution III, preparing a solution IV, adding accessorial ingredients, and carrying out mixing. The preparation process is reasonable and reliable, the manner of preparing intermediate solutions in advance and then carrying out vacuumizing mixing is adopted, so that the prepared gel is clear and transparent in property and good in teeth-cleaning effect, and has the efficacies of resisting inflammation, resisting allergy, and promoting the regrowth of the granulation tissue, meanwhile, the gel is combined with cetylpyridinium chloride, therefore, the pathogenic bacteria of the oral cavity can be inhibited, the formation of bacterial plaque can be prevented, the gel has very good curative effects for periodontal diseases, and finally, the oral health is maintained. In addition, the gel product does not contain an abrasive, the content of a foaming agent is low, therefore, the irritation to the oral mucosa is reduced, and the protection for the periodontal part is benefited.

Description

technical field [0001] The invention belongs to the technical field of oral care, and in particular relates to a production process of compound sodium azulene sulfonate tooth cleaning gel. Background technique [0002] As people's awareness of oral health continues to increase, the types of dental cleaning products on the market are increasing. However, in order to reduce production costs, a certain amount of abrasives and foaming agents are usually added to these dental cleaning products. Although It has a certain cleaning effect on the teeth, but long-term use will stimulate the oral mucosa, which is not conducive to the maintenance of periodontal health, and the properties of these dental cleaning products are relatively ordinary. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a production process of compound sodium azulene sulfonate tooth cleaning gel. [0004] In order to solve the problems of the technolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/34A61K8/368A61K8/44A61K8/46A61K8/49A61K8/60A61K8/73A61Q11/00A61Q17/00A61P1/02
CPCA61K8/922A61K8/345A61K8/368A61K8/44A61K8/466A61K8/4926A61K8/60A61K8/73A61K8/733A61K2800/262A61K2800/72A61Q11/00A61Q17/005
Inventor 江晶晶张振平周建兵
Owner 江苏恩为众心生物医药有限公司
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