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Breath freshening toothpaste capable of efficiently preventing and controlling helicobacter pylori and preparation method thereof

A technology of Helicobacter pylori and Helicobacter pylori, which is applied in dentistry, oral care, pharmaceutical formulations, etc., can solve the problems of not having the effect of killing Helicobacter pylori, and the antibacterial effect is not ideal, and achieve the effect of protecting oral health

Inactive Publication Date: 2019-11-29
江苏协合转化医学研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are some Chinese herbal health care toothpastes on the market, the antibacterial effect is not ideal enough, especially it does not have the effect of killing Helicobacter pylori

Method used

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  • Breath freshening toothpaste capable of efficiently preventing and controlling helicobacter pylori and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of Helicobacter pylori type IgY:

[0028] (1) Immunization of laying hens

[0029] The 38-week-old Bailaihang laying hens are raised in an ultra-clean workbench, and the feed and water (pH 6.2) need to be sterilized by high-pressure steam. Before the laying hens are immunized, the bacteria concentration is 10 9 -10 11 The CFU / mL Helicobacter pylori strain was used as the antigen, mixed with Freund's incomplete adjuvant 1:1 and pipetted to make it emulsified evenly to obtain the Helicobacter pylori strain emulsion. (Group A) Inject the pre-treated Helicobacter pylori strain emulsion on both sides of the chicken wings and the root of the thigh, 0.25 mL for each part, and immunize once every 7 days, for a total of 4 times. The laying hens of the control group (group B) were injected with an equal volume mixture of normal saline and Freund's incomplete adjuvant. The administration site and dosage were the same as those of the experimental group. Eggs were co...

Embodiment 2

[0035] Make the toothpaste of the control group and the toothpaste of the 3 experimental groups according to the following ratio, and the toothpastes of the 3 experimental groups are respectively named as experiment 1, experiment 2 and experiment 3.

[0036] Table 1 Raw material ratio of toothpaste

[0037]

[0038] The preparation method of toothpaste is as follows:

[0039] S1. Mix and stir the raw materials of component B evenly to obtain a mixed solution;

[0040] S2. Add component A to the mixed solution obtained in step S1, mix and stir evenly, and perform emulsification treatment to obtain a paste;

[0041] S3. Add component C to the paste obtained in step S2, mix and stir evenly, perform homogenization treatment, and vacuumize to obtain toothpaste.

Embodiment 3

[0043] Performance Testing

[0044] Investigate the experimental method of preventing and controlling Helicobacter pylori and removing bad breath with this product: Select 200 Hp positive patients and divide them into treatment group 1 (50 cases), treatment group 2 (50 cases), treatment group 3 (50 cases) and the control group (50 examples), treatment group 1, treatment group 2 and treatment group 3 respectively adopt the toothpaste brushing teeth that experiment 1, experiment 2 and experiment 3 in embodiment 2 obtain, every day 2 times (respectively once in the morning and evening), the matched group adopts embodiment The toothpaste obtained by the control group in 2 was twice a day in the morning and evening, and the use period was 2 months. After stopping the drug for 1 month, the negative rate and the removal of oral odor were counted. The results are as follows:

[0045] Table 2 Experimental results of prevention and control of Helicobacter pylori

[0046] tre...

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Abstract

The invention discloses a breath freshening toothpaste capable of efficiently preventing and controlling helicobacter pylori and a preparation method thereof, and particularly relates to the technicalfield of biology and chemical industry. Main components of the prepared toothpaste are tetravalent specific immune yolk sphere protein powder (tetravalence refers to (1) HapA adhesion, (2) Vac vacuolating cytotoxin, (3) CAG cytotoxin associated gene and (4) URE urease) and a natural plant extract moringa oleifera leaf powder, wherein the tetravalent specific immune yolk sphere protein powder is unique at home and abroad at present. The present invention has the following two functions: preventing and controlling helicobacter pylori in oral cavity; and removing oral odor. In addition, the toothpaste has certain protection effects on livers and stomachs, and simultaneously exerts an effect in preventing and controlling harmful bacteria in intestines and stomachs. The toothpaste has no toxicor side effects and can effectively protect oral health.

Description

technical field [0001] The invention belongs to the technical field of biology and chemical industry, and in particular relates to a breath-refreshing toothpaste for preventing and controlling Helicobacter pylori and a preparation method thereof. Background technique [0002] Oral Helicobacter pylori is a kind of bacteria in the oral cavity and stomach, which can cause stomach diseases. It often causes chronic gastrointestinal diseases and gastric ulcers. If measures are not taken in time, malignant lesions may occur and induce cancer. Helicobacter pylori mainly enters from the mouth. Once infected with Helicobacter pylori, it will stimulate the crazy secretion of gastric lactation, which will cause gastric acid, stomach pain, heartburn and other symptoms; Helicobacter pylori can also cause pain in patients. Mild cases are intermittent pain, while those with severe symptoms will be accompanied by severe colic, which will recur. Because Helicobacter pylori will cause a lot o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/64A61Q11/00A61P1/02A61P1/00A61P1/16
CPCA61K8/64A61Q11/00A61K8/9789A61P1/00A61P1/02A61P1/16
Inventor 张学记
Owner 江苏协合转化医学研究院有限公司
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