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Thermo-sensitive collagen compound anti-inflammatory gel spray for treating psoriasis and preparation method thereof

A temperature-sensitive, psoriasis technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, skin diseases, etc., can solve problems such as poor effect, skin repair, bacterial invasion, etc. Repair and treatment, prevent moisture evaporation, long-lasting effect

Inactive Publication Date: 2018-08-03
JIESHOU JINGHUA TECH INFORMATION CONSULTING SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the contrary, if the collagen production ability in the human dermis is insufficient, the skin collagen replenishment ability is defective, and the chapped skin cannot be repaired in time. The chapped parts are easily invaded and infected by some bacteria and fungi, causing redness, swelling and festering, and inflammatory skin diseases. common psoriasis
If the problem of lack of skin collagen is not solved, although psoriasis can be controlled and alleviated after anti-inflammatory and sterilization, it cannot fundamentally repair the skin, and there is still a window for bacterial invasion. From this study, it can be seen that psoriasis is a kind of skin collagen. Deficiency, the cause of the disease is not bacterial infection, but insufficient skin collagen production, resulting in a lack of skin damage repair ability, so Western medicine and traditional Chinese medicine use various conventional anti-inflammatory, sterilization and heat-clearing detoxification methods are not symptomatic treatment, so the effect has not been good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Preparation of thermosensitive collagen compound anti-inflammatory gel spray for treating psoriasis

[0050] The temperature-sensitive collagen-based composite anti-inflammatory gel spray for treating psoriasis in this embodiment is made of the following raw materials in parts by weight: temperature-sensitive collagen-based composite anti-bacterial and anti-inflammatory gel 55, hemostatic drug 18, dandelion 15, forsythia 4, Salvia miltiorrhiza 3, Rhizoma Chuanxiong 2, Speranthum 6, glycerin 10, rosemary essential oil 2.5, lauric monoglyceride 2.5, water 15; its preparation method comprises the following steps:

[0051] (1) Preparation of thermosensitive collagen-based composite antibacterial and anti-inflammatory gel

[0052] Take 3 parts by weight of type I collagen and dissolve it in 300 parts by volume of 10mM hydrochloric acid solution with stirring at 7°C. After the collagen is completely dissolved, slowly add pH The Tris-NaCl buffer solution with a value of 8.0 w...

Embodiment 2

[0059] Preparation of thermosensitive collagen compound anti-inflammatory gel spray for treating psoriasis

[0060] The temperature-sensitive collagen-based composite anti-inflammatory gel spray for treating psoriasis in this embodiment is made of the following raw materials in parts by weight: temperature-sensitive collagen-based composite anti-bacterial and anti-inflammatory gel 45, hemostatic drug 15, dandelion 12, forsythia 3, Salvia miltiorrhiza 2, Rhizoma Chuanxiong 1, Speranthema 4, glycerin 8, rosemary essential oil 2, monoglyceride laurate 1.5, water 10; its preparation method comprises the following steps:

[0061] Take 1 weight part of type I collagen and dissolve it in 100 volume parts of 10mM hydrochloric acid solution with stirring at 4°C. After the collagen is completely dissolved, slowly add pH The Tris-NaCl buffer solution with a value of 8.0 was stirred evenly at 4°C to obtain the regenerated collagen fiber buffer stock solution; then the above-mentioned rege...

Embodiment 3

[0068] Preparation of thermosensitive collagen compound anti-inflammatory gel spray for treating psoriasis

[0069] The temperature-sensitive collagen-based composite anti-inflammatory gel spray for treating psoriasis in this embodiment is made of the following raw materials in parts by weight: temperature-sensitive collagen-based composite anti-bacterial and anti-inflammatory gel 65, hemostatic drug 20, dandelion 18, forsythia 5, Salvia miltiorrhiza 4, Rhizoma Chuanxiong 3, Speranium 8, glycerin 12, rosemary essential oil 3, monoglyceride laurate 3.5, water 20; its preparation method comprises the following steps:

[0070] Take 5 parts by weight of type I collagen, stir it at 10°C and dissolve it in 500 parts by volume of 10mM hydrochloric acid solution. After the collagen is completely dissolved, slowly add pH The Tris-NaCl buffer solution with a value of 8.0 was stirred evenly at 10°C to obtain the regenerated collagen fiber buffer stock solution; then the above-mentioned r...

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Abstract

The invention discloses a thermo-sensitive collagen compound anti-inflammatory gel spray for treating psoriasis and a preparation method thereof. The thermo-sensitive collagen compound anti-inflammatory gel spray comprises the following raw materials in part by weight: 45-65 parts of thermo-sensitive collagen-based antibacterial and anti-inflammatory gel, 15-20 parts of hemostatic drug, 12-18 parts of dandelion, 3-5 parts of forsythia suspensa, 2-4 parts of radix salviae miltiorrhizae, 1-3 parts of ligusticum wallichii, 4-8 parts of tuberculate speranskia herbs, 8-12 parts of glycerinum, 2-3 parts of rosemary essential oil, 1.5-3.5 parts of glycerol monolaurate and 10-20 parts of water. The thermo-sensitive collagen compound anti-inflammatory gel spray for treating the psoriasis and the preparation method thereof disclosed by the invention have the benefits that according to research results on skin deficiency of collagens in a psoriasis patient, an antibacterial and anti-inflammatoryingredient is added based on the original efficacy of the thermo-sensitive collagen-based compound hemostatic gel; the treatment of both symptoms and root causes of the psoriasis is realized by adopting a method of direct collagen supplement and combination of sterilization and anti-inflammation with dietary supplement for a psoriasis diseased area. The thermo-sensitive collagen compound anti-inflammatory gel spray adopts a spray manner, is convenient to use and has very good application prospect.

Description

technical field [0001] The invention relates to the field of prevention and treatment of skin diseases, in particular to a temperature-sensitive collagen composite anti-inflammatory gel spray for treating psoriasis and a preparation method thereof. Background technique [0002] Psoriasis is a common chronic and easily relapsing inflammatory skin disease with characteristic skin lesions. It starts as an inflammatory red papule, about the size of a miliary grain to a mung bean, and then gradually expands or merges into a brownish-red plaque with clear borders and surrounding areas. There are inflammatory flushes, obvious basal infiltration, and the surface is covered with multiple layers of dry off-white or silver-white scales. Psoriasis is a stubborn skin disease that is difficult to cure so far. [0003] As we all know, collagen (Collagen) is ubiquitous in various tissues and organs of the human body, such as bones, cartilage, ligaments, skin, cornea, various endometrium, f...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K36/634A61K9/06A61K47/10A61K47/32A61K47/44A61P17/06
CPCA61K9/0014A61K9/06A61K36/185A61K36/236A61K36/288A61K36/47A61K36/537A61K36/634A61K38/39A61K47/10A61K47/32A61K47/44A61K2236/333A61K2236/51A61P17/06A61K2300/00
Inventor 应允通于浩淼邢宇
Owner JIESHOU JINGHUA TECH INFORMATION CONSULTING SERVICE CO LTD
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