Application of artemisinin derivative to preparation of medicine for preventing and treating 2-type diabetes mellitus and complications of diabetes mellitus and medicine composition

An artemisinin derivative, a technology for type 2 diabetes, applied in the field of biomedicine, can solve problems such as the application of artemisinin derivatives that have not yet been found, and achieve the effects of increasing respiratory quotient, reducing fasting blood sugar, and reducing excretion rate

Inactive Publication Date: 2018-08-17
SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The application of artemisinin derivatives in type ...

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  • Application of artemisinin derivative to preparation of medicine for preventing and treating 2-type diabetes mellitus and complications of diabetes mellitus and medicine composition
  • Application of artemisinin derivative to preparation of medicine for preventing and treating 2-type diabetes mellitus and complications of diabetes mellitus and medicine composition
  • Application of artemisinin derivative to preparation of medicine for preventing and treating 2-type diabetes mellitus and complications of diabetes mellitus and medicine composition

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Embodiment Construction

[0021] Embodiments of the present invention will be specifically described below in conjunction with the accompanying drawings.

[0022] Diabetes mainly causes hyperglycemia due to blood sugar utilization disorder, which in turn causes damage to various target organs, serious complications, high disability and mortality rates, and the pathogenesis is not yet fully understood.

[0023] The present invention aims to observe the prevention and treatment effect of artemisinin derivatives such as artemether on type 2 diabetes and its complications.

[0024] In order to achieve the above object, the present invention provides the following technical solutions:

[0025] 1. To study the effect of artemether treatment on the respiratory quotient of type 2 diabetic mice;

[0026] 2. To study the effect of artemether treatment on fasting blood glucose in type 2 diabetic mice;

[0027] 3. To study the effect of artemether treatment on polydipsia and polyuria in type 2 diabetic mice;

...

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Abstract

The invention relates to an application of an artemisinin derivative to preparation of a medicine for preventing and treating 2-type diabetes mellitus and complications of the 2-type diabetes mellitusand a medicine composition containing the artemisinin derivative. According to the application, experiments confirm that the artemisinin derivative such as artemether can increase the respiration quotient of the 2-type diabetes mellitus, oxidation of metabolic substrate glucose is facilitated, blood glucose of the 2-type diabetes mellitus is reduced, polydipsia and polyuria symptoms are improved,and urinary albumin excretion is decreased. The artemisinin derivative has an obvious protection effect on the 2-type diabetes mellitus and the complications thereof.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically relates to the application and pharmaceutical composition of artemisinin derivatives in the preparation of drugs for preventing and treating type 2 diabetes and its complications. Background technique [0002] Diabetes is a chronic non-communicable disease that seriously threatens human health and has a high prevalence. It is characterized by elevated blood sugar and can cause chronic damage to various tissues, especially the kidneys, heart, eyes, blood vessels, and nerves. In China, with the increasing prevalence of type 2 diabetes, diabetic nephropathy has gradually replaced glomerulonephritis as the leading cause of chronic kidney disease. [0003] Artemisinin (Q) is a sesquiterpene lactone drug with peroxy groups extracted from the plant Artemisia annua, and its common derivatives include dihydroartemisinin (DI), artesunate (Artesunate, ART), artemether (artemether, J), artee...

Claims

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Application Information

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IPC IPC(8): A61K31/357A61P3/10A61P7/12A61P13/12A61P13/00
CPCA61K31/357A61P3/10A61P7/12A61P13/00A61P13/12
Inventor 孙惠力韩鹏勋李顺民易铁钢邵牧民
Owner SHENZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
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