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Production method of targeted treatment medicinal pectin

A production method and targeted therapy technology, applied in the field of pectin extraction, can solve the problems of reducing the water solubility of pectin, and achieve the effects of increasing adhesion, enhancing effect, and increasing the degree of calcification

Inactive Publication Date: 2018-08-21
ANHUI YUNING PECTIN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But pectin, because of its hydrophilicity, makes it easy to swell in the body environment and release the drug early
Therefore, when pectin is made into medicine, calcium ions are usually added to calcify it to reduce the water solubility of pectin. Now, common pectin on the market is often used in the preparation of targeted drugs, and there are no pectin products specially produced for the characteristics of medicines.

Method used

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  • Production method of targeted treatment medicinal pectin

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Experimental program
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Effect test

Embodiment 1

[0019] A method for producing medicinal pectin for targeted therapy, the specific steps are as follows:

[0020] (1) Wash and crush citrus peels, boil in boiling water for 15-20 minutes, and filter to obtain pomace; (2) Squeeze the pomace in step (1) to remove excess water, then add EDTMPS aqueous solution to adjust the pH value to 3.5 , heat up to 30-40°C, heat and stir for 60-70min, filter to obtain the filter residue, and divide the filter residue into two parts on average, namely filter residue a and filter residue b;

[0021] (3) Add 2-3 times the volume of deionized water to the filter residue a in the above step (2), then add 0.001-0.03 times the volume of compound enzyme a, heat up to 60-70°C, keep warm for 12-15h, and then filter to obtain filter residue c;

[0022] (4) Add 2-3 times the volume of deionized water to the filter residue b in the above step (2), then add 0.001-0.03 times the volume of compound enzyme b, heat up to 60-70°C, keep warm for 12-15h, and then...

Embodiment 2

[0028] A method for producing medicinal pectin for targeted therapy, the specific steps are as follows:

[0029] (1) Wash and crush citrus peels, boil in boiling water for 15-20 minutes, and filter to obtain pomace; (2) Squeeze the pomace in step (1) to remove excess water, then add EDTMPS aqueous solution to adjust the pH value to 3.5 , heat up to 30-40°C, heat and stir for 60-70min, filter to obtain the filter residue, and divide the filter residue into two parts on average, namely filter residue a and filter residue b;

[0030] (3) Add 2-3 times the volume of deionized water to the filter residue a in the above step (2), then add 0.001-0.03 times the volume of compound enzyme a, heat up to 60-70°C, keep warm for 12-15h, and then filter to obtain filter residue c;

[0031] (4) Add 2-3 times the volume of deionized water to the filter residue b in the above step (2), then add 0.001-0.03 times the volume of compound enzyme b, heat up to 60-70°C, keep warm for 12-15h, and then...

Embodiment 3

[0038] A method for producing medicinal pectin for targeted therapy, the specific steps are as follows:

[0039] (1) Wash and crush citrus peels, boil in boiling water for 15-20 minutes, and filter to obtain pomace; (2) Squeeze the pomace in step (1) to remove excess water, then add EDTMPS aqueous solution to adjust the pH value to 3.5 , heat up to 30-40°C, heat and stir for 60-70min, filter to obtain the filter residue, and divide the filter residue into two parts on average, namely filter residue a and filter residue b;

[0040] (3) Add 2-3 times the volume of deionized water to the filter residue a in the above step (2), then add 0.001-0.03 times the volume of compound enzyme a, heat up to 60-70°C, keep warm for 12-15h, and then filter to obtain filter residue c;

[0041](4) Add 2-3 times the volume of deionized water to the filter residue b in the above step (2), then add 0.001-0.03 times the volume of compound enzyme b, heat up to 60-70°C, keep warm for 12-15h, and then ...

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Abstract

The invention provides a production method of targeted treatment medicinal pectin and relates to the technical field of pectin extraction. The pectin product is mainly prepared by the following steps:boiling and filtering citrus pomace, soaking by using EDTMPS water bath, dividing filter residues into two parts, performing fermentation treatment by using composite enzyme a and composition enzymeb separately, and combining and extracting the pectin. The product increases the calcification degree of a composite formed by combining the pectin and calcium ions when the targeted medicine is prepared and enhances the treatment effect of the medicine.

Description

technical field [0001] The invention relates to the technical field of pectin extraction, in particular to a production method of medicinal pectin for targeted therapy. Background technique [0002] Nowadays, pectin is widely used in the field of medicine, among which the use of colon targeted therapy in targeted therapy is particularly prominent. Since the drugs for colon targeted therapy are mainly administered orally to achieve the therapeutic effect, after taking the drug, the gastrointestinal The upper end of the tract is not released, and the drug is delivered to the ileocecal part of the human body and begins to disintegrate or erode and release, exerting local or systemic therapeutic effects in the colon. Oral colon-targeted drug delivery preparations are often used to treat colon diseases, such as colitis, colon cancer, etc., which can directly release the drug in the lesion area, so that the drug can play a more effective role. [0003] Pectin is a natural macromo...

Claims

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Application Information

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IPC IPC(8): C12P19/14C12P19/04
CPCC12P19/04C12P19/14
Inventor 谢保明刘帅
Owner ANHUI YUNING PECTIN CO LTD
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