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Purification crystallization process and system for extracting β-alanine from enzyme conversion solution

A crystallization system and enzymatic conversion technology, applied in the field of bioengineering, can solve the problems of filter membrane pollution, low adsorption effect, affecting the purity and yield of β-alanine, and achieve the effect of improving adsorption and effect.

Inactive Publication Date: 2022-01-07
成都本则生科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention solves the filter membrane pollution problem existing in the technology of extracting and purifying β-alanine from the enzyme conversion liquid in the prior art, and the technology that the adsorption effect of activated carbon is low, which affects the purity and yield of β-alanine problem, and further provide a purification and crystallization process of β-alanine that can effectively improve the adsorption effect on bacteria, proteins, pigments and other substances, improve the purity and yield of β-alanine, and reduce membrane fouling. At the same time, a system for realizing the above process is provided

Method used

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  • Purification crystallization process and system for extracting β-alanine from enzyme conversion solution
  • Purification crystallization process and system for extracting β-alanine from enzyme conversion solution
  • Purification crystallization process and system for extracting β-alanine from enzyme conversion solution

Examples

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Embodiment 1

[0041] The purification and crystallization system for extracting β-alanine from the enzyme conversion solution provided in this example, such as figure 1 As shown, it includes: a decolorization treatment device 1, a chamber is provided in the decolorization treatment device 1, and a liquid inlet and an activated carbon powder dosing port of the decolorization treatment device 1 are arranged on the chamber, containing β- The enzymatic conversion liquid of alanine enters the chamber through the liquid inlet, and the activated carbon powder is used to decolorize the enzymatic conversion liquid, and a first pH adjustment device is arranged in the chamber; The decolorization treatment device 1 adopts a stirring tank, and a stirring device is arranged in the stirring tank, and the stirring tank is provided with a heating device, which is suitable for regulating the temperature in the tank, and the first pH adjusting device includes an acid liquid dripping pipe, Alkali dripping tube...

Embodiment 2

[0048] The purification and crystallization system for extracting β-alanine from the enzyme conversion solution provided in this example, such as figure 2 As shown, it includes: an adsorption device 8, which can use diatomite particles to perform adsorption treatment on the enzyme conversion solution containing β-alanine.

[0049] The decolorization treatment device 1 is provided with a chamber in the decolorization treatment device 1, and the liquid inlet and the activated carbon powder feeding port of the decolorization treatment device 1 are arranged on the chamber, and the enzyme containing β-alanine The conversion liquid enters the chamber through the liquid inlet, and decolorizes the enzyme conversion liquid by using activated carbon powder, and a first pH adjustment device is arranged in the chamber for adjusting The pH value of the enzyme conversion solution; the decolorization treatment device 1 described in the present embodiment adopts a stirred tank, and a stirrin...

Embodiment 3

[0059] The purification and crystallization system for extracting β-alanine from the enzyme conversion solution provided in this example is the same as that in Example 2.

[0060] The diatomite particles used in this example are diatomite particles modified by cationic surfactants. In this embodiment, the method for modifying the diatomite particles is as follows: weigh a certain amount of diatomite particles with a particle size range of 0.8-1.5mm, and then weigh a certain amount of cationic surfactant. The cationic surfactant used in the embodiment is cetyltrimethylammonium bromide, the consumption of described cationic surfactant and the consumption of described diatomaceous earth particle are 1:25 in mass ratio, add pure water Afterwards, heat to 75° C., and place for 4 hours in a state of heat preservation and stirring to complete the modification reaction. Wherein after adding pure water, the concentration of the cationic surfactant in the pure water is 1g / L. After the...

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Abstract

The invention provides a purification and crystallization process for extracting β-alanine from an enzyme conversion liquid and a system thereof, the process adjusts the pH value of the enzyme conversion liquid containing β-alanine to 5-6, and utilizes activated carbon powder to Perform decolorization treatment on the enzyme conversion solution, and then adjust the pH value to 7-7.5 for subsequent treatment. Under this pH value condition, the adsorption of the activated carbon powder to pigments and impurities can be greatly improved, thereby making the activated carbon decolorization treatment The effect of the method has been significantly improved, which makes up for the problem of the existing technology that the decolorization effect is affected by the presence of a large amount of colloids and macromolecular proteins in the conversion solution.

Description

technical field [0001] The invention belongs to the field of bioengineering, and specifically relates to a process for purifying, crystallizing and extracting β-alanine in an enzyme conversion solution and a process for realizing the system. Background technique [0002] β-alanine (3-aminopropionic acid) is an intermediate in the field of medicine and a precursor for the synthesis of pantothenic acid. Pantothenic acid is a type of B vitamin and has the function of producing antibodies. important role in blood health. In addition to the pharmaceutical field, β-alanine can also be used as a wastewater flocculant in water treatment, as a moisturizing factor in cosmetics, and as a sweetener synthesis in the food field, etc. Due to its wide application, the market demand for β-alanine There is also a gradual upward trend. [0003] The synthetic methods of β-alanine include chemical synthesis and biosynthesis. Among them, the chemical synthesis method is a relatively extensive ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/40C07C227/42C07C229/08B01D15/22B01D9/02
CPCB01D9/0059B01D15/22B01D15/245B01D15/247C07C227/40C07C227/42B01D2009/0086C07C229/08
Inventor 吴红光
Owner 成都本则生科技有限公司
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