Liquid crystal gel hepatic artery embolic agent and preparation method thereof

Abstract

The invention discloses a liquid crystal gel hepatic artery embolic agent and a preparation method thereof, wherein the liquid crystal gel hepatic artery embolic agent is mainly formed by mixing 85-95wt% of an A phase and 5-15 wt% of a B phase, and the A phase comprises 33-52 wt% of at least one diacylglycerol, 33-52 wt% of at least one phosphatidylcholine and 0-15 wt% of a surfactant; the B phase comprises 8-20 wt% of a solvent and 80-92 wt% of an active ingredient; the active ingredient is an anti-tumor drug; diacylglycerol comprises glycerol dioleate; phosphatidylcholine comprises soybeanphosphatidylcholine; and the solvent is ethanol. With use of the consisting composition of the liquid crystal gel and unique liquid crystal phase structure, the release of a carrier can be effectivelycontrolled, the circulation time in vivo is prolonged, and the bioavailability is improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a liquid crystal gel hepatic artery embolization agent and a preparation method thereof. Background technique [0002] Liquid crystal is a molecular aggregate with long-range order and short-range disorder. It is the fourth state besides the three states of matter. It is a thermodynamically stable intermediate phase state between solid and liquid. On the one hand, it has a flow like a liquid. On the other hand, it has anisotropy like crystal, which is a kind of substance with special structure. Liquid crystals can be divided into lyotropic liquid crystals and thermotropic liquid crystals. Lyotropic liquid crystals are mainly a system formed by two or more components under certain conditions. This system is mostly composed of amphiphilic molecules and solvents. When amphiphilic molecules and solvents When mixed, the solvent impregnates the solid lattice of a...

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Problems solved by technology

However, the above-mentioned embolic materials have certain defects, such as poor fluidity of gelatin sponge, poor dispersion of microspheres, and liquid embolic materials are prone to cause vascular toxicity, etc.

Based on the theoretical basis that amphiphilic liquid crystal materials and water can self-assemble into thermodynamically stable systems with different structures, scientists use the unique structure, bio-affinity and stability characteristics of cubic liquid crystals to prepare solvent-induced liquid crystal solutions by using in-situ gel technology , but most of them use liquid crystal materials such as glycerol monooleate and phytantriol to prepare gels. Although they have good embolism properties and good biocompatibility, a certain concentration of unsaturated monofatty acids Glycerides can cause hemolysis in animals

Han Ke "Research on Hepatic Artery Embolic Agent Based on Phytantriol Cubic Liquid Crystal" - (2010.06) proposed to use phytantriol as liquid crystal material to prepare embolism, although it has good embolism performance, but a certain concentration of phytantriol It is easy to cause hemolysis. CN103120640A patent introduces a preparation method of embolic agent, in which liposomes are wrapped with 131I-iodol and magnetic nanoparticles, and the magnetic nanoparticles are dispersed in the 131I-iodol. There are anti-tumor drugs on the face, but this preparation method is too complicated, and the time stability of lipiodol embolization is poor

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