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Method for producing Liushenqu by pure-bred fermentation of Monascus and its use for lowering blood fat

A kind of Monascus, pure-bred fermentation technology, applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, cardiovascular system diseases, etc., can solve the fermentation effect is not necessarily achieved, the difference is large, the stable difference of product quality and other problems to achieve the effect of stable product quality

Active Publication Date: 2021-04-02
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The proportion of flour and wheat bran in the original formula of Liushenqu is quite different in the production methods of different manufacturers, and the stability of product quality is also quite different
In the fermentation method, some people also try to apply pure-bred fermentation, such as patent CN105267249, which utilizes chrysanthemum-producing penicillin to carry out pure-bred fermentation to produce Liushenqu. Therefore, its fermentation effect may not be able to achieve the original effect of co-fermentation of multiple strains

Method used

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  • Method for producing Liushenqu by pure-bred fermentation of Monascus and its use for lowering blood fat
  • Method for producing Liushenqu by pure-bred fermentation of Monascus and its use for lowering blood fat

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Effect test

Embodiment 1

[0027] This embodiment relates to a method for producing Liushenqu by fermenting pure species of Monascus. The strain used for the pure-bred fermentation can be: one of Monascus ruberus (M.ruber), Monascus purple (M.purpureus) or Monascus pilosus (M.pilosus);

[0028] The six raw materials of Liushenqu are preferably highland barley, Artemisia annua, pepper, cocklebur, red bean and bitter almond;

[0029] The pure-bred fermentation preparation process of Liushenqu is as follows:

[0030] (1) Experimental materials

[0031] The strain Monascusruber-3.5834 (purchased from the Institute of Microbiology, Chinese Academy of Sciences) was stored on a PDA agar slant medium, and barley replaced the flour and wheat bran in the original recipe, cocklebur, Polygonum punctatus, red bean, bitter almond, and Artemisia annua , glucose, KH 2 PO 4 , MgSO 4 .7H 2 O, CaCO 3 , peptone, yeast extract, water.

[0032] (2) Experimental process

[0033] Strain activation: prepare 500ml of No...

Embodiment 2

[0041] Embodiment 2, effect verification

[0042] Raising conditions for hamsters: positive pressure purification and ventilation animal room, room temperature 24±2°C, humidity 40-70%, artificial lighting to simulate diurnal changes, free to eat and drink. 60 male golden hamsters were randomly divided into 5 groups: normal group, model group, lovastatin control group, red yeast song control group, and Liushenqu group. Except for the normal group, all the other groups were given high-fat feed, and were intragastrically administered according to the designed dose. The experiment period was 2 months. After the experiment, blood was taken from the orbit, the serum was separated, and the total cholesterol (TC) and triglyceride (TG) contents were determined. It can be seen from Table 1 that the lipid-lowering effect of Liushenqu is better than that of the lovastatin group and the red yeast rice group, especially the lowering effect on triglycerides is particularly significant.

...

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Abstract

The invention discloses a method for producing Liushenqu by pure-bred fermentation of Monascus fungus and its anti-blood lipid application; (M.pilosus) is a single-fermentation strain, using six raw materials of highland barley, Artemisia annua, Xanthium annua, pepper, bitter almond and red bean as the base material of the culture medium, and fermented under suitable conditions to produce six Divine Comedy. The Liushenqu prepared by the process has the effects of invigorating the spleen and harmonizing the stomach, promoting blood circulation and removing blood stasis, and can be used for the prevention and treatment of hyperlipidemia and related cardiovascular diseases.

Description

technical field [0001] The invention relates to the field of production and application of traditional Chinese medicines, in particular to a method for producing Liushenqu by fermenting pure species of Monascus and its use for lowering blood lipids. Background technique [0002] The preparation method of the Six Divine Comedy is recorded in "Shen Nong's Materia Medica" as "on May 5th or June 6th, take a hundred catties of white flour and three liters of Artemisia annua natural juice to match white tiger, green dragon, rosefinch, basalt, hook Chen and Tengshe Liushen, use flour and juice, beans, almonds to make cakes, wrapped in hemp leaves or Chu leaves, such as the method of making yellow sauce, wait for raw yellow clothes, dry and harvest." However, the standards of the Six Divine Comedies recorded in the bibliographies of the past dynasties are not the same, and there are status quo such as the same name but different classifications, the same drug prescriptions with diff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61K36/28A61K36/282A61K36/48A61K36/704A61K36/736A61P3/06A61P9/10A61K31/366A61K31/22
CPCA61K31/22A61K31/366A61K36/28A61K36/282A61K36/48A61K36/704A61K36/736A61K36/899A61K2236/19A61P3/06A61P9/10A61K2300/00
Inventor 王玉亮唐克轩何敏孙小芬
Owner SHANGHAI JIAOTONG UNIV
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