Recombinant turkey herpesvirus vaccine strain coexpressing H5 subtype avian influenza HA protein and infectious bursal VP2 protein

A technology of turkey herpes virus and avian influenza virus, which is applied in the direction of double-stranded RNA virus, double-stranded DNA virus, antisense single-stranded RNA virus, etc., and can solve problems such as interference, spreading virus, and many side effects

Inactive Publication Date: 2018-09-18
HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although traditional vaccines can provide effective protection to poultry, they also have many shortcomings. For example, the disadvantages of inactivated vaccines for avian influenza are poor immunogenicity, many side effects, and large dosages. [2] The disadvantages of infectious bursal disease vaccines mainly include: attenuated live vaccines are susceptible to interference from maternal antibodies; moderately virulent live vaccines can damage the bursa and have the risk of spreading the virus; inactivated vaccines cannot Induce the body to produce strong immunity, unable to resist the attack of strong virus strains, etc. [3]

Method used

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  • Recombinant turkey herpesvirus vaccine strain coexpressing H5 subtype avian influenza HA protein and infectious bursal VP2 protein
  • Recombinant turkey herpesvirus vaccine strain coexpressing H5 subtype avian influenza HA protein and infectious bursal VP2 protein
  • Recombinant turkey herpesvirus vaccine strain coexpressing H5 subtype avian influenza HA protein and infectious bursal VP2 protein

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Embodiment Construction

[0030] The present invention will be further described below with reference to specific examples, but those skilled in the art should understand that the present invention is not limited to these specific examples.

[0031] Reagents and the like used in the following embodiments are commercially available products unless otherwise specified.

[0032] 1 material

[0033] 1.1 Virus strains, plasmids and cell lines

[0034] Turkey herpes virus (HVT) strain FC126 was purchased from the China Veterinary Drug Control Institute; avian influenza virus strain A / Chicken / Guizhou / 4 / 2013 (H5N1) (CK / GZ / 4 / 13 for short) was purchased from the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences The National Avian Influenza Reference Laboratory was isolated and preserved. The infectious bursal virus IBDV HLJ-0504 strain was provided by the Innovation Team of Poultry Immunosuppressive Diseases, Harbin Veterinary Research Institute, Chinese Academy of Agricultura...

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Abstract

The invention relates to a recombinant turkey herpesvirus vaccine strain coexpressing an H5 subtype avian influenza HA protein and an infectious bursal VP2 protein, and an application thereof. The preservation number of the recombinant turkey herpesvirus vaccine strain coexpressing H5 subtype avian influenza HA gene and infectious bursal VP2 gene is CCTCC NO:V201738. The invention also provides atriple vaccine for preventing avian influenza virus, infectious bursal disease virus and Marek virus. The triple vaccine comprises an effective amount of the recombinant turkey herpesvirus vaccine strain coexpressing the H5 subtype avian influenza HA gene and the infectious bursal VP2 gene.

Description

[0001] This application claims the priority of the invention patent application 201711428339.1 submitted on December 25, 2017. technical field [0002] The invention relates to a recombinant virus vaccine, in particular to a recombinant turkey herpes virus vaccine strain co-expressing H5 subtype avian influenza HA protein and infectious bursa VP2 protein and application thereof. Background technique [0003] Avian influenza virus (Avain influenza virus, AIV) and infectious bursa virus (Infectious bursa disease virus, IBDV) are two important viral infectious diseases that endanger the development of my country's poultry industry, causing serious economic losses to the poultry industry. [1] . Currently, the main means of controlling these two infectious diseases is immunization with vaccines. Although traditional vaccines can provide effective protection to poultry, they also have many shortcomings. For example, the disadvantages of inactivated avian influenza vaccines are po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/12A61P31/14A61K39/145A61P31/16A61K39/245A61P31/22C12N15/85C12N7/01C12R1/93
CPCA61K39/12A61P31/14A61P31/16A61P31/22C12N7/00C12N15/85C07K14/005C12N2720/10022C12N2720/10034C12N2710/16334C12N2710/16321C12N2760/16134C12N2760/16122A61K2039/70A61K2300/00
Inventor 陈化兰陈普成姜永萍柳金雄邓国华曾显营高立
Owner HARBIN VETERINARY RES INST CHINESE ACADEMY OF AGRI SCI
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