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Applications of carbazole compound in preparation of drugs or health care food used for treating metabolic diseases and complications of metabolic diseases

A technology for metabolic diseases and health food, applied in the direction of metabolic diseases, functions and applications of food ingredients, etc., can solve problems such as single use, no introduction of drug use methods, unfavorable use of patients, etc., to prevent and treat fatty liver and protect ischemia Myocardial injury, the effect of good application prospects

Active Publication Date: 2018-10-09
SHANGHAI TENTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent application: CN104997771A discloses the application of a compound P7C3-A20 in the preparation of drugs for the treatment of cerebral ischemic diseases. The invention confirms through cell experiments that P7C3-A20 can improve the cerebral cortex of mice cultured in vitro in the hypoxia and glucose deficiency model. The survival rate of neurons. Animal experiments have confirmed that P7C3-A20 can significantly reduce the size of cerebral infarction caused by middle cerebral artery occlusion in rats. These results show that P7C3-A20 has a protective effect on cerebral ischemia and can prevent brain damage caused by cerebral ischemia. , has broad application prospects in the preparation of cerebral ischemic injury and / or cerebral infarction-related drugs, but the patent only shows that compound P7C3-A20 is used to prepare drugs for the treatment of cerebral ischemic diseases, the use is relatively single, and does not introduce the drug Method of use, not conducive to patient use
[0006] But about the application of a kind of carbazole compound of the present invention in the medicine or the health food of preparation treatment metabolic disease and complication thereof, there is no report yet

Method used

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  • Applications of carbazole compound in preparation of drugs or health care food used for treating metabolic diseases and complications of metabolic diseases
  • Applications of carbazole compound in preparation of drugs or health care food used for treating metabolic diseases and complications of metabolic diseases
  • Applications of carbazole compound in preparation of drugs or health care food used for treating metabolic diseases and complications of metabolic diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation of the medicine of embodiment 1 treatment metabolic disease and complication thereof (1)

[0032] Purchase P7C3-A20 from Shanghai Lanke Pharmaceutical Technology Development Co., Ltd., dissolve 10 mg of P7C3-A20 in 100 microliters of dimethyl sulfoxide (purchased from Sigma, commercially available), and then add 1 ml of castor oil (purchased in Shanghai Sinopharm Chemical Reagent Company, commercially available), and then use 5% dextrose (purchased from Shanghai Sinopharm Chemical Reagent Company, commercially available) to make up to 10ml, which can be used for administration.

Embodiment 2

[0033] Embodiment 2 Preparation of medicines for treating metabolic diseases and complications thereof (two)

[0034] Purchase P7C3-A20 from Shanghai Lanke Pharmaceutical Technology Development Co., Ltd., dissolve 10 mg of P7C3-A20 in 100 microliters of dimethyl sulfoxide (purchased from Sigma, commercially available), and then add 1 ml of castor oil (purchased in Shanghai Sinopharm Chemical Reagent Company, commercially available), and then use 5% dextrose (purchased from Shanghai Sinopharm Chemical Reagent Company, commercially available) to be settled to 10ml, and the above prepared medicine is prepared according to the conventional preparation method of granules Granules can be prepared by performing granulation, drying, sizing, quality inspection, dose division, packaging and storage.

Embodiment 3

[0035] Example 3 Preparation of Medicines for Treatment of Metabolic Diseases and Their Complications (3)

[0036] Purchase P7C3-A20 from Shanghai Lanke Pharmaceutical Technology Development Co., Ltd., dissolve 10 mg of P7C3-A20 in 100 microliters of dimethyl sulfoxide (purchased from Sigma, commercially available), and then add 1 ml of castor oil (purchased in Shanghai Sinopharm Chemical Reagent Company, commercially available), then use 5% dextrose (purchased from Shanghai Sinopharm Chemical Reagent Company, commercially available) to be settled to 10ml, and the above prepared medicine is prepared according to the conventional capsule preparation method Carry out drug mixing, capsule filling, capsule dedusting and cleaning, inspection, and packaging to prepare capsules.

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Abstract

The invention relates to applications of carbazole compound in preparation of drugs or health care food used for treating metabolic diseases and complications of metabolic diseases. The carbazole compound is 3, 6-dibromo-beta-fluorine-N-(3-methoxyphenyl)-9H-carbazole-9-propylanmine (P7C3-A20). It is confirmed through high fat high sugar diet induced hyperlipidemia, obesity, and fatty liver animalmodel experiments that P7C3-A20 is capable reducing blood fat, blood sugar, obesity, and fatty liver lesion obviously; it is confirmed by cardiac muscle cell ischemic anoxic model simulated ischemic myocardial injury that P7C3-A20 is capable of reducing myocardial cell injury caused by ischemia and anoxia. The advantages are that: 1, the carbazole compound is capable of reducing blood fat, blood sugar, obesity, and fatty liver lesion obviously, preventing and treating fatty liver, and avoiding ischemic myocardial injury; and 2, a novel drug research direction is provided for metabolic bone disease and complications of metabolic bone diseases, and the application prospect is promising.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a carbazole compound in the preparation of medicine or health food for treating metabolic diseases and their complications. Background technique [0002] In modern life, there are a lot of high-oil, high-sugar, and high-fat foods. Although this kind of food is delicious and attractive, if it is consumed too much, it will lead to a series of metabolic problems such as hyperlipidemia, hyperglycemia, obesity and even fatty liver. If these metabolic disorders persist, they will cause direct damage to various human tissues and organs, and easily induce complications, namely cardiovascular diseases, such as myocardial ischemia, which are life-threatening. Therefore, attention has been paid to transcription factors involved in induction of expression of adipocyte differentiation marker genes. Peroxisome Proliferator Activated Receptor (hereinafter also referred to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/403A61P3/00A61P3/06A61P3/10A61P3/04A61P1/16A61P9/10A23L33/10
CPCA23L33/10A23V2002/00A61K31/403A61P1/16A61P3/00A61P3/04A61P3/06A61P3/10A61P9/10A23V2200/326A23V2200/3262A23V2200/328A23V2200/332
Inventor 王培李冬洁
Owner SHANGHAI TENTH PEOPLES HOSPITAL
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