The invention discloses a health medical wine with the function of reducing three highs and a preparation method thereof. The heath medical wine is prepared from the following raw materials in parts by weight: 20-30 parts of lumbrukinase, 25-30 parts of hirudin, 5-15 parts of cassia occidentalis, 10-15 parts of fructus crataegi, 5-8 parts of dried orange peel, 15-20 parts of folium ginkgo, 6-12 parts of fructus lycii, 101-15 parts of flos chrysanthemi, 5-8 parts of fourstamen stephania root, 20-25 parts of radix puerariae, 5-8 parts of radix aristolochiae, 6-8 parts of radix aucklandiae, 10-15parts of flos chrysanthemi indici, 9-18 parts of catharanthus roseus, 4-8 parts of fructus forsythiae, 9-15 parts of selfheal, 2-6 parts of radix astragali, 3-7 parts of poria cocos, 3-6 parts of rhizoma atractylodis, 3-6 parts of rhizoma atractylodis, 10-18 parts of Chinese yam, 5-10 parts of rhizoma polygonati, 5-10 parts of rhizoma rehmanniae, 5-15 parts of radix scrophulariae, 5-10 parts of radix ophiopogonis, 5-8 parts of blueberry, 5-8 parts of mulberry, 6-12 parts of fagopyrum esculentum, 8-15 parts of benincasa hispida and 3-7 parts of radix notoginseng. The health medical wine can effectively reduce blood sugar, lipid and blood pressure, softens blood vessels, ensures the safety of three-high crowds and the stable diseases, and is good in health-care effect.