Lachnum sp., extracellular polysaccharide thereof and application of extracellular polysaccharide in lipid-lowering liver-favoring medicaments

A technology of Trichomyces granulosa and exopolysaccharide, applied in the direction of drug combination, microbial-based methods, medical preparations containing active ingredients, etc., can solve problems such as lowering fat and benefiting the liver, and achieve non-toxic side effects, relief and treatment Abnormal liver function, relief and treatment of liver damage and the effect of

Inactive Publication Date: 2011-11-23
HEFEI UNIV OF TECH
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0006] However, there is no report about the new strain Trichomonas granulosa YM-281 (the abbreviation of the number code YeMing-281 self-defined by the inventor's research group) and the exopolysaccharide prepared by it have the effect of lowering fat and benefiting the liver.

Method used

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  • Lachnum sp., extracellular polysaccharide thereof and application of extracellular polysaccharide in lipid-lowering liver-favoring medicaments
  • Lachnum sp., extracellular polysaccharide thereof and application of extracellular polysaccharide in lipid-lowering liver-favoring medicaments
  • Lachnum sp., extracellular polysaccharide thereof and application of extracellular polysaccharide in lipid-lowering liver-favoring medicaments

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Embodiment 1

[0024] Preparation of the extracellular polysaccharide of Trichosanthis YM-281:

[0025] In the present embodiment, the preparation process of the extracellular polysaccharide of Trichosanthis YM-281 is as follows:

[0026] Inoculate the YM-281 strain of Trichoderma spp with the deposit number CCTCC No: M 2011196 on a solid activation medium at 25-28°C for 6-8 days. The solid activation medium consists of 20-25g / L glucose and peptone 4-6g / L, 4-6g / L yeast extract, 14-16g / L agar; then inoculate activated Trichoderma YM-281 into a 250mL Erlenmeyer flask containing 100-125mL fermentation medium, 24-25℃, 180-200r / min constant temperature shaking culture for 3-4 days, as a large tank fermentation seed liquid, the fermentation medium consists of glucose 45-47g / L, yeast extract 14-15g / L, glycine 6-7mg / L, 0.9-1.1g / L MgSO 4 ·7H 2 O and 0.9-1.1g / L KH 2 PO 4 And adjust the initial pH to 7.0-8.0 with 0.3-0.5mol / L NaOH solution; then use a 5L self-controlled fermentor for liquid submerged ferm...

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Abstract

The invention discloses Lachnum sp., an extracellular polysaccharide thereof and application of the extracellular polysaccharide in preparing lipid-lowering liver-favoring medicaments. The invention is characterized in that a Lachnum sp. strain with the collection number of CCTCC (China Center for Type Culture Collection) No: M 2011196 is activated and inoculated to a fermentation culture medium, thus preparing the Lachnum sp. extracellular polysaccharide. When the administration dosage is 150-300 mg / (kg bw), the prepared Lachnum sp. extracellular polysaccharide can significantly lower the levels of serum lipid and liver lipid and atherosis index of high-lipid mice, and increase the level of serum high-density lipoprotein cholesterol and the excretion amount of feces lipid. When the administration dosage is 75-300 mg / (kg bw), the prepared Lachnum sp. extracellular polysaccharide can significantly lower the activity of serum aminotransferase and malondialdehyde content in liver tissues of high-lipid mice, and increase the activity of sudismase in the liver tissues. The prepared Lachnum sp. extracellular polysaccharide has obvious effects of lowering blood lipid, lowering liver lipid, and treating hepatic injury and dysfunction caused by high lipid, has no toxic or side effects, and can be prepared into tablets or capsules for clinical application.

Description

Technical field [0001] The present invention belongs to the technical field of the application of Verticillium granulosum and its extracellular polysaccharides, and in particular relates to the technical field of Verticillium granulosum YM-281 and its extracellular polysaccharides and its application in the preparation of lipid-lowering and liver-reducing drugs. Background technique [0002] With the continuous improvement of people's living standards, the intake of high-fat foods has gradually increased, and the incidence of diseases such as atherosclerosis, fatty liver and cardiovascular and cerebrovascular diseases has increased year by year. According to "Food Hydrocolloids" (Food Hydrocolloids, 2005, 19: 813-819), high fat (blood fat, liver fat) is the main cause of atherosclerosis and cardiovascular and cerebrovascular diseases. According to the "Chinese Journal of Traditional Chinese Medicine" (2010, 28(8): 1738-1740), high fat has potential damage to the liver, causing li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14C12P19/04A61K31/715A61P1/16A61P3/06C12R1/645
Inventor 叶明邱涛
Owner HEFEI UNIV OF TECH
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