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Lachnum sp., extracellular polysaccharide thereof and application of extracellular polysaccharide in lipid-lowering liver-favoring medicaments

A technology of Trichomyces granulosa and exopolysaccharide, applied in the direction of drug combination, microbial-based methods, medical preparations containing active ingredients, etc., can solve the problems of lowering fat and benefiting the liver, achieving no toxic side effects, increasing superoxide Dismutase activity, the effect of reducing serum transaminase activity

Inactive Publication Date: 2013-04-03
HEFEI UNIV OF TECH
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  • Abstract
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  • Claims
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Problems solved by technology

[0006] But at present, there are no reports about the new strain Trichodia granulosa YM-281 (the abbreviation of the number code YeMing-281 self-defined by the inventor's research group) and the exopolysaccharide prepared from it have the effect of lowering fat and benefiting the liver.

Method used

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  • Lachnum sp., extracellular polysaccharide thereof and application of extracellular polysaccharide in lipid-lowering liver-favoring medicaments
  • Lachnum sp., extracellular polysaccharide thereof and application of extracellular polysaccharide in lipid-lowering liver-favoring medicaments
  • Lachnum sp., extracellular polysaccharide thereof and application of extracellular polysaccharide in lipid-lowering liver-favoring medicaments

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Embodiment 1

[0024] Trichodia granulosa CCTCC No:M 2011196 Exopolysaccharide preparation:

[0025] In the present embodiment, the preparation process of Trichodia granulosus CCTCC No:M 2011196 exopolysaccharide is as follows:

[0026] Inoculate the Trichomonas strain with the preservation number CCTCC No: M 2011196 on a solid activation medium at 25-28°C for 6-8 days, the solid activation medium consists of 20-25g / L glucose, 4-6g / L peptone L, 4-6gL yeast extract, composed of 14-16g / L agar; then inoculate the activated Trichomonas CCTCC No:M 2011196 strain into a 250mL Erlenmeyer flask containing 100-125mL fermentation medium, at 24-25 Cultivate at a constant temperature of 180-200r / min for 3-4 days, as the seed liquid for large tank fermentation. The fermentation medium consists of glucose 45-47g / L, yeast extract 14-15gL, glycine 6-7mg / L, 0.9- 1.1g / L MgSO 4 ·7H 2 O and 0.9-1.1g / L KH 2 PO 4 composition, and adjust its initial pH at 7.0-8.0 with 0.3-0.5mol / L NaOH solution; The temperat...

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Abstract

The invention discloses Lachnum sp., an extracellular polysaccharide thereof and application of the extracellular polysaccharide in preparing lipid-lowering liver-favoring medicaments. The invention is characterized in that a Lachnum sp. strain with the collection number of CCTCC (China Center for Type Culture Collection) No: M 2011196 is activated and inoculated to a fermentation culture medium, thus preparing the Lachnum sp. extracellular polysaccharide. When the administration dosage is 150-300 mg / (kg bw), the prepared Lachnum sp. extracellular polysaccharide can significantly lower the levels of serum lipid and liver lipid and atherosis index of high-lipid mice, and increase the level of serum high-density lipoprotein cholesterol and the excretion amount of feces lipid. When the administration dosage is 75-300 mg / (kg bw), the prepared Lachnum sp. extracellular polysaccharide can significantly lower the activity of serum aminotransferase and malondialdehyde content in liver tissues of high-lipid mice, and increase the activity of sudismase in the liver tissues. The prepared Lachnum sp. extracellular polysaccharide has obvious effects of lowering blood lipid, lowering liver lipid, and treating hepatic injury and dysfunction caused by high lipid, has no toxic or side effects, and can be prepared into tablets or capsules for clinical application.

Description

technical field [0001] The invention belongs to the technical field of application of Trichodia granulosa and its extracellular polysaccharide, and in particular relates to Trichodia granulosa CCTCC No: M 2011196 and its exopolysaccharide and its application in the preparation of lipid-lowering and liver-reinforcing drugs. Background technique [0002] With the continuous improvement of people's living standards, the intake of high-fat food has gradually increased, and the incidence of diseases such as atherosclerosis, fatty liver and cardiovascular and cerebrovascular diseases has increased year by year. According to "Food Hydrocolloids" (Food Hydrocolloids, 2005, 19:813-819), high fat (blood fat, liver fat) is the main cause of atherosclerosis, cardiovascular and cerebrovascular diseases. According to "Chinese Journal of Traditional Chinese Medicine" (2010,28(8):1738-1740), high fat has potential damage to the liver, which will lead to liver damage and dysfunction. [000...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/14C12P19/04A61K31/715A61P1/16A61P3/06C12R1/645
Inventor 叶明邱涛
Owner HEFEI UNIV OF TECH
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