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Levofloxacin hydrochloride capsule

A technology of levofloxacin hydrochloride and capsules, which is applied in capsule delivery, plant raw materials, organic active ingredients, etc., can solve the problems of drug resistance, reduce the therapeutic effect, and decrease the drug effect, so as to reduce drug resistance, improve the therapeutic effect, and take safe effect

Inactive Publication Date: 2018-10-09
江苏黄河药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bacteria have a certain tolerance to antibacterial drugs. Once drug resistance occurs, the effect of the drug will be significantly reduced; this will lead to the resistance of some bacteria to levofloxacin, thereby reducing its therapeutic effect

Method used

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  • Levofloxacin hydrochloride capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A levofloxacin hydrochloride capsule, prepared from levofloxacin hydrochloride with a mass ratio of 3:4:3:2, an auxiliary agent mixture, an auxiliary antibiotic and a Chinese herbal medicine mixture; wherein the auxiliary antibiotic is benzyl penicillin;

[0032] The auxiliary agent mixture includes a filler, a disintegrant, a lubricant, an antioxidant and a surfactant in a mass ratio of 15:4:3:2.5:1.5; wherein the filler is lactose; the disintegrator is sodium starch glycolate; The lubricant is talcum powder; the antioxidant is potassium sorbate; the surfactant is lecithin;

[0033] The Chinese herbal medicine mixture includes honeysuckle and isatis root, wherein the weight ratio of honeysuckle and isatis root is 3:2.

[0034] The preparation method of levofloxacin hydrochloride capsules comprises the following steps:

[0035] 1) Take levofloxacin hydrochloride, auxiliary agent mixture, auxiliary antibiotic and Chinese herbal medicine mixture in proportion;

[0036] ...

Embodiment 2

[0042] A levofloxacin hydrochloride capsule, prepared from levofloxacin hydrochloride with a mass ratio of 3:5.5:6:10, an auxiliary agent mixture, an auxiliary antibiotic and a Chinese herbal medicine mixture; wherein, the auxiliary antibiotic is benzyl penicillin;

[0043] The auxiliary agent mixture includes a filler, a disintegrant, a lubricant, an antioxidant and a surfactant in a mass ratio of 15:9:7:5.5:3; wherein, the filler is lactose; the disintegrator is sodium starch glycolate; The lubricant is talcum powder; the antioxidant is potassium sorbate; the surfactant is lecithin;

[0044] The Chinese herbal medicine mixture includes honeysuckle and isatis root, wherein the weight ratio of honeysuckle and isatis root is 3:6.

[0045] The preparation method of levofloxacin hydrochloride capsules comprises the following steps:

[0046] 1) Referring to Example 1, take levofloxacin hydrochloride, auxiliary agent mixture, auxiliary antibiotic and Chinese herbal medicine mixtur...

Embodiment 3

[0053] A levofloxacin hydrochloride capsule, prepared from levofloxacin hydrochloride with a mass ratio of 3:7:9:18, an auxiliary agent mixture, an auxiliary antibiotic and a Chinese herbal medicine mixture; wherein, the auxiliary antibiotic is benzylpenicillin;

[0054] The auxiliary agent mixture includes a filler, a disintegrant, a lubricant, an antioxidant and a surfactant in a mass ratio of 15:13:11:7.5:4.5; wherein the filler is lactose; the disintegrator is sodium starch glycolate; The lubricant is talcum powder; the antioxidant is potassium sorbate; the surfactant is lecithin;

[0055] The Chinese herbal medicine mixture includes honeysuckle and isatis root, wherein the weight ratio of honeysuckle and isatis root is 3:11.

[0056] The preparation method of levofloxacin hydrochloride capsules comprises the following steps:

[0057] 1) Referring to Example 1, take levofloxacin hydrochloride, auxiliary agent mixture, auxiliary antibiotic and Chinese herbal medicine mixtu...

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Abstract

The invention relates to the technical field of levofloxacin preparations and particularly relates to a levofloxacin hydrochloride capsule which is prepared from levofloxacin hydrochloride, an additive mixture, assistant antibiotics, and a Chinese herbal medicine mixture. By organically integrating the components, the capsule has effect of treating both exterior and interior by compounding Chineseand Western medicines, and antibacterial range of the capsule is broadened. Meanwhile, drug resistance of bacteria against the levofloxacin hydrochloride can be reduced, so that the capsule is a preparation having high effect and broad-spectrum antibacterial function. The capsule enlarges the antibacterial spectrum and improves treatment effect of the levofloxacin hydrochloride.

Description

technical field [0001] The invention relates to the technical field of levofloxacin preparations, in particular to a levofloxacin hydrochloride capsule. Background technique [0002] Levofloxacin is the levoisomer of ofloxacin, a fluoroquinolone. It was first successfully developed by Japan's Daiichi Pharmaceutical Co., Ltd. in 1994 and launched in Japan, and was allowed to enter China in 1995. [0003] Levofloxacin is an optical isomer of ofloxacin. The antibacterial activity in vitro is about twice that of ofloxacin, and the toxic and side effects are greatly reduced. It is one of the best varieties of quinolones at present. Levofloxacin is effective against most aerobic Gram-positive bacteria and Gram-negative bacteria, and has moderate efficacy against anaerobic bacteria. Data show that levofloxacin is sensitive to Klebsiella pneumoniae, Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epiphysis and Streptococcus ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5383A61K9/48A61K36/355A61P31/04A61K31/545A61K31/496A61K31/431A61K31/43
CPCA61K9/4858A61K9/4866A61K31/43A61K31/431A61K31/496A61K31/5383A61K31/545A61K36/195A61K36/315A61K36/355A61P31/04A61K2300/00
Inventor 张汉华朱正标曹群闫海粟范小雪
Owner 江苏黄河药业股份有限公司
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