A kind of toltrazuril inclusion compound freeze-dried powder and preparation method thereof

A technology of toltrazuril and inclusion complex, applied in the field of toltrazuril inclusion complex freeze-dried powder and preparation thereof, can solve the problems of poor stability, poor water solubility of toltrazuril, limited therapeutic effect, etc. Solubility, the effect of enriching the dosage form
CN108653217BInactive Publication Date: 2020-01-10SICHUAN AGRI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SICHUAN AGRI UNIV
Publication Date
2020-01-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses toltrazuril inclusion compound lyophilized powder. The toltrazuril inclusion compound lyophilized powder is obtained by adopting sulfobutyl ether-beta-cyclodextrin to perform inclusion on toltrazuril and then carrying out a lyophilization process. A preparation method of the toltrazuril inclusion compound lyophilized powder concretely comprises the following steps: dissolving the toltrazuril by an organic solvent to obtain an organic solution of the toltrazuril; adding the organic solution of the toltrazuril into an aqueous solution of the sulfobutyl ether-beta-cyclodextrin, and magnetically stirring for carrying out a reaction; carrying out rotary evaporation on the materials obtained after the reaction so as to remove the organic solvent, then filtering by using amicrofiltration membrane and drying to obtain a toltrazuril inclusion compound; carrying out the lyophilization process to obtain the toltrazuril inclusion compound lyophilized powder. According to the preparation method, the sulfobutyl ether-beta-cyclodextrin is adopted to perform inclusion on the toltrazuril, so that the solubility of the indissolvable drug-the toltrazuril is improved; by adopting the lyophilization process, the stability and bioavailability of the toltrazuril are improved; the toltrazuril inclusion compound lyophilized powder enriches the preparations of antiparasitic drugs.
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Description

technical field

[0001] The present invention relates to an inclusion compound and the technical field of preparation thereof, in particular to a freeze-dried powder of Toltrazuril inclusion compound and a preparation method thereof. Background technique

[0002] Toltrazuril (tohrazuril) is a triazinone anticoccidial drug developed by Bayer AG in the 1980s. Its trade name is Baycox, and it is called toltrazuril solution in China. The drug can effectively kill a variety of protozoa including coccidia. It is a highly effective anticoccidial drug with a very wide anti-coccidian spectrum, low toxicity, and slow drug resistance. It is widely used in livestock and poultry coccidia at home and abroad. Disease prevention and treatment.

[0003] The dosage forms of toltrazuril are mainly powder and drinking water, but their water solubility is poor. During use, due to its low concentration and poor stability of toltrazuril, it is prone to precipitation and discoloration, which greatl...

Claims

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