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Application of quercetin in preparation of drug for treating CP (chronic prostatitis)

A technology for chronic prostatitis and prostatitis, which can be used in drug combinations, sexual diseases, pharmaceutical formulations, etc., and can solve problems such as difficulty in obtaining clinical efficacy.

Inactive Publication Date: 2018-10-16
BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Conventional treatment methods (such as antibacterial agents, α-receptor blockers, anti-inflammatory drugs, plant therapy, hormone therapy and other therapies and even surgical treatment) are difficult to obtain ideal clinical efficacy

Method used

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  • Application of quercetin in preparation of drug for treating CP (chronic prostatitis)
  • Application of quercetin in preparation of drug for treating CP (chronic prostatitis)
  • Application of quercetin in preparation of drug for treating CP (chronic prostatitis)

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, the therapeutic effect of quercetin on chronic prostatitis

[0021] The rat model of nonbacterial prostatitis was prepared with complete Freund's adjuvant.

[0022] 1. Preparation of quercetin solution

[0023] The solvent is hydroxypropyl-β-cyclodextrin solution, and the preparation method is as follows: hydroxypropyl-β-cyclodextrin is dissolved in double distilled water to make the concentration 25g / 100ml.

[0024] Prepare 1g / 100ml quercetin solution, 2g / 100ml quercetin solution and 4g / 100ml quercetin solution respectively. The preparation method of quercetin solution: weigh quercetin, add solvent, mix with a magnetic stirrer for 30 minutes, store at 4°C, return to room temperature and mix thoroughly before each administration.

[0025] Two, group processing

[0026] Thirty-nine 6-week-old male SD rats, weighing 240-260g, were routinely fed for 1 week and then grouped as follows:

[0027] Normal group (6 rats): without any treatment;

[0028] Model ...

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Abstract

The invention discloses an application of quercetin in preparation of a drug for treating CP (chronic prostatitis) and a drug which is used for treating nonbacterial prostatitis and has the active component of quercetin. It is found that the quercetin can reduce the prostate index and reduce infiltration of inflammatory cells in prostate mesenchyme on the premise that the body weight is not affected, which indicates that the quercetin has the significant inhibition effect on the CP in histology; the quercetin can significantly reduce levels of inflammatory cell factors IL-1beta, IL-2, IL-6 andTNF-alpha in prostatitis tissue, which proves that the quercetin has the significant anti-inflammatory function on the CP; the quercetin can significantly improve antioxidant enzyme activity in bodies and reduce production of oxidative stress products, which indicates that the quercetin has the significant antioxidation effect on the CP. The results prove that the quercetin has significant treatment effects on the CP, and the foundation is laid for development of clinical drugs.

Description

technical field [0001] The invention relates to a new application of quercetin, that is, the application of quercetin in the preparation of medicine for treating chronic prostatitis. Background technique [0002] Prostatitis is one of the most common diseases in urology, second only to benign prostatic hyperplasia and prostate cancer, and ranks third in common male urinary tract diseases. In 1995, the National Institutes of Health (NIH) of the United States divided prostatitis into four categories: type I, which is equivalent to acute bacterial prostatitis in the traditional classification method; type II, which is equivalent to chronic bacterial prostatitis in the traditional classification method; Type III, chronic prostatitis / chronic pelvic pain syndrome; type IV, asymptomatic prostatitis. Among prostatitis, chronic prostatitis / chronic pelvic pain syndrome (CP / CPPS) accounts for the vast majority. Conventional treatment methods (such as antibacterial agents, α-receptor ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P13/08A61P15/00
CPCA61K31/352A61P13/08A61P15/00
Inventor 邢念增孟令全杨飞亚
Owner BEIJING CHAOYANG HOSPITAL CAPITAL MEDICAL UNIV
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