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New preparation method of 3-hydroxybenzoyl chloride

A technology of hydroxybenzoyl chloride and hydroxybenzoic acid, which is applied in the field of medicine, can solve the problems of unstable yield, low yield of 3-hydroxybenzoyl chloride, complex synthesis process, etc., and achieve the effect of high procurement cost

Inactive Publication Date: 2018-10-23
SHANGHAI HUAJIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The yield of the existing 3-hydroxybenzoyl chloride preparation method is not high, the synthesis process is complicated, and the yield is unstable. It is necessary to invent a new preparation method to overcome the deficiencies of the prior art, in order to achieve energy saving, environmental protection, green the goal of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1: Preparation of 3-hydroxybenzoyl chloride:

[0008] 1381 mg of 3-hydroxybenzoic acid was added to the reactor, 50 ml of toluene was added, and while stirring, 3 ml of N,N-dimethylformamide was added at room temperature, and then stirred at room temperature for 20 minutes, and then the reaction was carried out in an oil bath. The temperature of the solution was heated to 60°C, 3 g of thionyl chloride was added dropwise, and the reaction was continued to stir at 60°C for 4 hours. After the completion of the reaction, the compound 3-hydroxybenzoyl chloride was obtained through post-treatment and purification process, and the yield was 73.6%.

Embodiment 2

[0009] Example 2: Preparation of 3-hydroxybenzoyl chloride:

[0010] 1381 mg of 3-hydroxybenzoic acid was added to the reactor, 50 ml of toluene was added, and while stirring, 3 ml of N,N-dimethylformamide was added at room temperature, and then stirred at room temperature for 20 minutes, and then the reaction was carried out in an oil bath. The temperature of the solution was heated to 60°C, 3 g of thionyl chloride was added dropwise, and the reaction was continued to stir at 60°C for 4 hours. After the completion of the reaction, the compound 3-hydroxybenzoyl chloride was obtained through post-treatment and purification process, and the yield was 76.3%.

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PUM

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Abstract

The invention relates to a new preparation method of 3-hydroxybenzoyl chloride, belonging to the technical field of medical technology. The invention relates to a more advanced new preparation methodof the 3-hydroxybenzoyl chloride. In order to solve the technical problems, the invention is characterized by providing the new preparation method of the compound. The chemical structure formula of the compound is described in the description.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a new preparation method of 3-hydroxybenzoyl chloride. Background technique [0002] 3-Hydroxybenzoyl chloride is an important intermediate raw material for the synthesis of pharmaceutical products. [0003] The yield of the existing preparation method of 3-hydroxybenzoyl chloride is not high, the synthesis process is complex, and the yield is unstable. It is necessary to invent a new preparation method to overcome the deficiencies of the prior art, in order to achieve energy saving, environmental protection, green the goal of. SUMMARY OF THE INVENTION [0004] The present invention adopts a new technology, aiming at the shortcomings of the existing preparation method of 3-hydroxybenzoyl chloride that the yield is not high, the synthesis process is complex, the yield is unstable, and the procurement cost of the required raw materials is high. A new preparation method was inv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/60C07C65/03
CPCC07C51/60C07C65/03
Inventor 不公告发明人
Owner SHANGHAI HUAJIN BIOTECH CO LTD
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