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MicroRNA marker combination for identifying cause subtype of ischemic stroke and application of microRNA marker combination

A technology of ischemic stroke and markers, applied in the field of precise diagnosis, can solve problems such as plasma circulating miRNA assessment, and achieve the effects of easy mass typing, high specificity, simple and safe operation

Inactive Publication Date: 2018-11-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, plasma circulating miRNA expression has not been assessed in different ischemic stroke subtypes

Method used

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  • MicroRNA marker combination for identifying cause subtype of ischemic stroke and application of microRNA marker combination
  • MicroRNA marker combination for identifying cause subtype of ischemic stroke and application of microRNA marker combination
  • MicroRNA marker combination for identifying cause subtype of ischemic stroke and application of microRNA marker combination

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Embodiment

[0035] The following examples are used herein to demonstrate preferred embodiments of the invention. It should be appreciated by those of skill in the art that the techniques disclosed in the examples which follow represent techniques discovered by the inventors to be employed in the practice of the invention, and thus can be considered preferred modes for its practice. However, those skilled in the art should understand from this specification that many modifications can be made to the specific embodiments disclosed herein, and the same or similar results can still be obtained without departing from the spirit or scope of the present invention.

[0036] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention belongs, and the disclosures cited herein and their cited materials are all incorporated by reference .

[0037]Those skilled in the art will recognize, or b...

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Abstract

The invention provides a microRNA marker combination for identifying the cause subtype of ischemic stroke. The microRNA marker combination comprises at least one of miR-125b, miR-125a, miR-let-7b, miR-let-7e, miR-7-2-3p and miR-1908. The invention further provides application of the microRNA marker combination in preparation of a reagent for identifying cause subtype of the ischemic stroke and application of the microRNA marker combination to preparation of a reagent for forecasting the stroke risk of a testee. The invention further provides a kit comprising a reagent capable of detecting thecontent of the marker combination. The microRNA marker combination provided by the invention for parting the ischemic stroke has the characteristics of simple and safe operation, high sensitivity, high specificity and easiness in massive parting.

Description

technical field [0001] The invention belongs to the field of precise diagnosis, and in particular relates to a microRNA marker of an etiological subtype of ischemic stroke and its application. Background technique [0002] Ischemic stroke (IS) is the leading cause of death and long-term disability in developed countries, with approximately 80% of strokes being ischemic. In China, there are 2.5 million strokes and 1 million deaths from stroke-related causes every year. Ischemic stroke is a highly heterogeneous disease. The vast majority of acute coronary syndromes are due to atherosclerosis of large and medium arteries. Ischemic stroke may also be due to other etiologies, including intracranial small vessel disease, cardioembolism, and blood disorders. The prognosis and management of ischemic stroke is directly related to the specific mechanism of ischemic injury. Comparing clinical features, functional outcomes, and mortality for specific ischemic stroke mechanisms may a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/178
Inventor 桂雅星
Owner ZHEJIANG UNIV
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