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Preparation method and application of nanometer silver-pueraria root fiber dressing

A kudzu root fiber and nano-silver technology, which is applied in fiber treatment, pharmaceutical formulations, bandages, etc., to achieve good hemostasis, repair injured tissue, and large specific surface area

Active Publication Date: 2020-12-04
ZHEJIANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But in fact, in addition to puerarin, Pueraria lobata contains at least 12-18% flavonoids due to different varieties. Flavonoids can expand peripheral blood vessels, improve microcirculation, remove putrefaction and promote granulation, and relieve heat and astringe. And other hemostatic materials, plus kudzu root fiber after special treatment, has the characteristics of loose tissue and strong adsorption force. The combination of the two actually has the possibility of becoming a high-end rapid hemostatic material, but there is little research on this aspect in China

Method used

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  • Preparation method and application of nanometer silver-pueraria root fiber dressing

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Experimental program
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Effect test

Embodiment 1

[0025] The preparation method and application of embodiment 1 nanometer silver-pueraria root fiber dressing X1

[0026] Include the following steps:

[0027] Use 1 L of H at a concentration of 1 mL / L 2 SO 4 Dissolve 250g of Pueraria root powder, place it in a water bath at 40°C for 45min, rinse with tap water until the pH of the solution reaches 7; then add 30mL Na with a concentration of 30mL / L 2 SiO 3 solution, 100mL of MgSO with a mass concentration of 12.75g / L 4 solution, 210 mL of NaOH solution with a mass concentration of 40 g / mL and 660 mL of H 2 o 2 Mix the resulting mixture, place it in a water bath at 85°C for 80 minutes, and stir for 10 minutes; then add 400 mL of Ag with a concentration of 1.5 g / L 2 SO 4 solution so that the pH of the solution to 7;. Filtrate with a Buchner funnel to obtain the silver-pueraria fiber precipitate; wash the silver-pueraria fiber precipitate with warm water at 30°C until the pH value on the surface of the silver-pueraria fiber ...

Embodiment 2

[0029] The preparation method and application of embodiment 2 nanometer silver-pueraria root fiber dressing X2

[0030] Include the following steps:

[0031] Use 0.4 L of H at a concentration of 1 mL / L 2 SO 4 Dissolve 100g of pueraria root powder, place it in a water bath at 40°C for 45min, rinse with tap water until the pH of the solution reaches 7.3; then add 12mL of Na with a concentration of 30mL / L 2 SiO 3 solution, 40mL of MgSO with a mass concentration of 12.75g / L 4 solution, 84 mL of NaOH solution with a mass concentration of 40 g / mL and 264 mL of H 2 o 2 Mix the resulting mixture, place it in a water bath at 85°C for 80 minutes, and stir for 5 minutes; then add 160 mL of Ag with a concentration of 1.5 g / L 2 SO 4 solution so that the pH of the solution to 7.4;. Filtrate with a Buchner funnel to obtain the silver-pueraria fiber precipitate; wash the silver-pueraria fiber precipitate with warm water at 50°C until the pH value on the surface of the silver-pueraria ...

Embodiment 3

[0033] The preparation method and application of embodiment 3 nanometer silver-pueraria root fiber dressing X3

[0034] Use 0.1 L of H at a concentration of 1 mL / L 2 SO 4 Dissolve 25g of pueraria root powder, place it in a water bath at 40°C for 45min, rinse with tap water until the pH of the solution is 6.8; then add 3mL Na with a concentration of 30mL / L 2 SiO 3 solution, 10mL of MgSO with a mass concentration of 12.75g / L 4 solution, 21 mL of NaOH solution with a mass concentration of 40 g / mL and 66 mL of H 2 o 2 Mix the resulting mixture, place it in a water bath at 85°C for 80 minutes, and stir for 7 minutes; then add 40 mL of Ag with a concentration of 1.5 g / L 2 SO 4 solution so that the pH of the solution to 7.1;. Filtrate with a Buchner funnel to obtain the silver-pueraria fiber precipitate; wash the silver-pueraria fiber precipitate with warm water at 50°C until the pH value on the surface of the silver-pueraria fiber precipitate is 7.1; after dissolving with 75%...

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Abstract

A preparation method of a nanometer silver-kudzu vine root fiber dressing is provided. The method includes subjecting kudzu vine root fibers to degumming treatment by utilizing a Ag2SO4 solution and generating a silver-kudzu vine root fiber precipitate; subjecting the surface of the silver-kudzu vine root fiber precipitate to neutralization treatment; dissolving the treated silver-kudzu vine rootfiber precipitate with an ethanol solution having a concentration of 75%; performing ultrasonic vibration until the solution becomes a stable yellow solution to form a kudzu vine root fiber-nanometersilver mixture agent; adding poly(vinylidene fluoride), dimethylsulfoxide, fatty acid polyethylene glycol ester and a surfactant into the kudzu vine root fiber-nanometer silver mixture agent; performing ultrasonic vibration until the mixture is uniform to prepare an electrostatic spinning solution; and spinning with the electrostatic spinning solution to obtain the dressing. Through the method, flavonoids in kudzu vine roots are maintained in kudzu vine root cellulose in a high ratio so that the prepared dressing has advantages of capability of rapid bleeding arresting, good breathability andhigh antibacterial capability.

Description

technical field [0001] The invention belongs to the technical field of biomanufacturing, in particular to a preparation method and application of a nano silver-pueraria root fiber dressing. Background technique [0002] Since blood loss is one of the most important causes of death for war wounded, the multi-functional high-end rapid hemostatic dressing is an important tool for first aid on the battlefield and in various daily trauma situations. Blood loss from war injuries is usually divided into internal bleeding and external bleeding. Internal bleeding is mostly due to organ rupture, and external bleeding is basically due to arteriovenous injury. If the bleeding can be stopped in time and effectively, it is very important to save the life of the wounded, stabilize the injury, and create conditions for follow-up treatment. Dressing, as a hemostatic material, refers to a protective covering on the wound, which can help control bleeding, prevent infection and absorb secretio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/40A61L15/44A61L15/42A61L15/18A61L15/46A61L15/24A61L15/26D01D5/00
CPCA61L15/18A61L15/24A61L15/26A61L15/40A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/104A61L2300/30A61L2300/404A61L2300/418A61L2400/04D01D5/0015C08L27/16C08L71/02
Inventor 宋娜陈建荣丁林贤杨利宁
Owner ZHEJIANG NORMAL UNIVERSITY
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