A kind of resveratrol composite membrane agent and preparation method thereof

A technology of resveratrol and composite film agent, which is applied to the resveratrol composite film agent, the preparation field of the above-mentioned resveratrol composite film agent, can solve the problem of poor mechanics, anti-ultraviolet, limited application, and expensive polylactic acid and other problems, to achieve the effect of slow release and improved compatibility

Active Publication Date: 2020-09-29
TIANJIN UNIV OF SCI & TECH
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, polylactic acid is expensive and has poor mechanical and anti-ultraviolet properties, which greatly limit its application in the field of biomedicine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0017] Example: Preparation of L-polylactic acid / alkali lignin grafted D-polylactic acid / resveratrol film

[0018] Dissolve 0.1g of alkali lignin in 10mL of N,N-dimethylformamide (DMF), stir for 20min to dissolve it completely, and obtain an alkali lignin / DMF solution with a concentration of 10% (w / w); add 2.9 g of D-lactide (D-LA) and 0.077g of 4-dimethylaminopyridine (DMAP), then heated to 80°C and reacted for 24h. After the reaction is finished, cool to room temperature, add deionized water to wash, and dry to obtain alkali lignin grafted D-polylactic acid copolymer.

[0019] Take 5 mg of the alkali lignin grafted D-polylactic acid copolymer and 0.5 g of L-polylactic acid in Example 1 and dissolve them in 2 mL of chloroform respectively, add 10 mg of resveratrol after mixing, and ultrasonically treat for 5 minutes to mix evenly, then place it Stir on a magnetic stirrer for 1h, 600r / min; finally cast the resulting solution on a polytetrafluoroethylene plate, and after the s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
Login to view more

Abstract

The invention relates to a resveratrol composite film agent. The film agent takes L-polylactic acid and lignin-grafted D-polylactic acid copolymer as a main film forming material; by utilizing a solution blending method and simultaneously introducing resveratrol, the composite film agent with good mechanical property, thermal stability, UV resistance, biocompatibility and drug slow release is prepared in a compounding manner. On one hand, a stereocomplex formed by L-polylactic acid and D-polylactic acid molecular chains can significantly improve the compatibility of the polylactic acid with the lignin and improve the mechanical properties of the lactic acids; on the other hand, the lignin and resveratrol have a similar polyphenol structure and a certain ultraviolet resistance, so that thestability of the resveratrol can be improved, and the long-acting release is realized.

Description

technical field [0001] The invention belongs to the field of functional polymer materials and biomedicine. Specifically relates to a resveratrol composite membrane agent. [0002] The invention also relates to a preparation method of the above-mentioned resveratrol composite film agent. Background technique [0003] Resveratrol is a plant complement mainly found in seed plants and belongs to the non-flavonoid polyphenolic compounds. Studies have found that in addition to improving plant disease resistance, resveratrol has a variety of biological effects, such as cardiovascular protection, anti-inflammation, blood lipid regulation, and inhibition of platelet aggregation. [0004] Implantable drug delivery system (IDDS) is a kind of drug release preparation that is surgically implanted or punctured into the body or subcutaneously, and is a long-term drug delivery system. IDDS can increase the drug concentration in specific parts, make the drug closer to the target tissue, a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04C08L87/00C08K5/13C08G83/00C08J5/18
CPCC08G83/00C08J5/18C08J2367/04C08J2487/00C08K5/13
Inventor 戴林邹竹帆周文琴
Owner TIANJIN UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap