A kind of resveratrol composite membrane agent and preparation method thereof

Abstract

The invention relates to a resveratrol composite film agent. The film agent takes L-polylactic acid and lignin-grafted D-polylactic acid copolymer as a main film forming material; by utilizing a solution blending method and simultaneously introducing resveratrol, the composite film agent with good mechanical property, thermal stability, UV resistance, biocompatibility and drug slow release is prepared in a compounding manner. On one hand, a stereocomplex formed by L-polylactic acid and D-polylactic acid molecular chains can significantly improve the compatibility of the polylactic acid with the lignin and improve the mechanical properties of the lactic acids; on the other hand, the lignin and resveratrol have a similar polyphenol structure and a certain ultraviolet resistance, so that thestability of the resveratrol can be improved, and the long-acting release is realized.

Description

technical field

[0001] The invention belongs to the field of functional polymer materials and biomedicine. Specifically relates to a resveratrol composite membrane agent.

[0002] The invention also relates to a preparation method of the above-mentioned resveratrol composite film agent. Background technique

[0003] Resveratrol is a plant complement mainly found in seed plants and belongs to the non-flavonoid polyphenolic compounds. Studies have found that in addition to improving plant disease resistance, resveratrol has a variety of biological effects, such as cardiovascular protection, anti-inflammation, blood lipid regulation, and inhibition of platelet aggregation.

[0004] Implantable drug delivery system (IDDS) is a kind of drug release preparation that is surgically implanted or punctured into the body or subcutaneously, and is a long-term drug delivery system. IDDS can increase the drug concentration in specific parts, make the drug closer to the target tissue, a...