Application of LncRNA in serum as marker to URSA diagnosis and pregnancy outcome evaluation

A technology of markers and outcomes, applied in the field of biomedicine, can solve the problems of low diagnostic efficiency, achieve high diagnostic accuracy, high detection sensitivity, and meet the detection requirements

Active Publication Date: 2018-11-06
INST OF BASIC MEDICINE OF SAMS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there are reports on the application of LncRNAs in the auxiliary diagnosis and treatment of recurrent miscarriage, their diagnostic efficiency is low.

Method used

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  • Application of LncRNA in serum as marker to URSA diagnosis and pregnancy outcome evaluation
  • Application of LncRNA in serum as marker to URSA diagnosis and pregnancy outcome evaluation
  • Application of LncRNA in serum as marker to URSA diagnosis and pregnancy outcome evaluation

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Embodiment Construction

[0031] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0032] It should be noted that the terminology used here is only for describing specific embodiments, and is not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations and / or combinations thereof.

[0033] Explanation of terms:

[0034] LncRNA NONHSAT167899.1: long-chain non-coding ribonucleic acid LncRNA NONHSAT167899.1, the nucleic acid sequence of ...

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Abstract

The invention discloses application of LncRNA NONHSAT167899.1 as a marker URSA diagnosis and pregnancy outcome evaluation and develops a corresponding detection kit by taking LncRNA NONHSAT167899.1 asa marker for diagnosing URSA and evaluating pregnancy outcome. The kit is high in detection sensitivity, high in specificity and convenient to detect; the detection requirements of patients with URSAcan be met; clinical experiments show that the accuracy rate of the diagnosis is high.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of LncRNA NONHSAT167899.1 in serum as a marker for the diagnosis of unexplained recurrent spontaneous abortion (URSA) and pregnancy outcome assessment. Background technique [0002] Spontaneous abortion occurs twice or more in a row, which is called recurrent spontaneous abortion (RSA). The incidence rate is about 1% to 5% of women of childbearing age. The etiology is complex, except for a few chromosomes, endocrine, anatomy, infection and other factors. In addition, about 80% of the cause is unknown, known as unexplained recurrent spontaneous abortion (unexplained recurrentspontaneous abortion, URSA). URSA seriously endangers the reproductive health of women of childbearing age, but currently there is a lack of biological indicators with strong specificity, high sensitivity, and good stability. There is no clear and unified standard for clinical intervention...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12Q1/6837C12N15/113
CPCC12Q1/6837C12Q1/6883C12Q2600/178
Inventor 李霞王彬赵霖张华张振尹训强张云虹魏然郭强朱肖肖
Owner INST OF BASIC MEDICINE OF SAMS
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