Unlock instant, AI-driven research and patent intelligence for your innovation.

Neuron parameter fitting method

A parameter fitting, neuron technology, applied in the field of neuroscience, to achieve the effect of improving operating efficiency

Pending Publication Date: 2018-11-06
COMMUNICATION UNIVERSITY OF CHINA
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some of these software are programmed by CPU, and some only provide a very simple GUI interface. There is still a lot of room for improvement in terms of speed and practicability.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Neuron parameter fitting method
  • Neuron parameter fitting method
  • Neuron parameter fitting method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0057] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention.

[0058] figure 1 It is a structural diagram of a neuron parameter fitting device in an embodiment of the present invention, mainly including an input or data acquisition module 11, a genetic algorithm module 12, and a parameter display module 13, wherein:

[0059] The main function of inputting or obtaining data module 11 is to import real biological experiment data or generate pseudo-experimental data by this software, and the data includes spike time point data and current data.

[0060] The generation of pseudo-experimental data such as image 3 shown, including the following steps:

[0061] Step S31 Input of stimulation current for each segment.

[0062] Step S32 selects the ion channel and inputs the corresponding conductance parameter value and some parameters of the H...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a neuron parameter fitting method capable of improving the fitting efficiency of neuron parameters, and belongs to the technical field of neurosciences. In reality, the restoration of a real neuron discharge activity is significant, the kinds of ion channels included by a certain neuron can be measured in an experiment, but conductance values of the ion channels are not easily measured. According to the method, the process of calculating a conductance parameter of a neuron model by a genetic algorithm is accelerated by employing CUDA programming, calculating resources ofa GPU are fully used, and the process of algorithm solution is visualized by employing an MFC frame. The tool can generate dummy experiment data to inspect an operation result of the tool through introduction of experiment data or according to the specified conductance parameter value and a stimulation current, and the usage for experiment personnel is facilitated. It is displayed by an experiment result that the algorithm can find the value similar to an optimal parameter so that an electric signal measured by the experiment can be reproduced.

Description

Technical field: [0001] The present invention belongs to the field of neuroscience. It is a method that uses a parallel genetic algorithm to fit experimental data to find parameters. This method can effectively improve the efficiency of neuron parameter fitting. Background technique [0002] For the HH model containing multiple ion channels, the expression is as follows In the experiment, we can measure the type of ion channel contained in a certain neuron, if the conductance parameter is known , we can solve the above differential equation to get the voltage value V at each moment, so that we can use this equation to simulate the real neuron firing activity. How to find the optimal parameters is very difficult. For example, in the experiment of measuring electrical signals, even if the type of ion channel contained in the neuron cell is known, it is difficult to simulate the firing activity of the cell, because it is usually very difficult in the experiment. It is dif...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G06N3/08G06N3/06G06N3/12
CPCG06N3/061G06N3/082G06N3/126
Inventor 曹立宏沈佳敏王晔宫妍竹
Owner COMMUNICATION UNIVERSITY OF CHINA