Food based delivery of therapeutic agent for treatment of hepatic encephalopathy

Abstract

Described herein are compositions, methods, and kits for treating hepatic encephalopathy. A composition for treating or preventing hepatic encephalopathy comprises one or more therapeutic agents and adelivery modality comprising an edible food, beverage, candy, or gum. The one or more therapeutic agents are mixed with one or more food ingredients so that the therapeutic agent is incorporated in the delivery modality.

Description

[0001] cross reference [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 276,683, filed January 8, 2016, and U.S. Provisional Application No. 62 / 276,685, filed January 8, 2016, both of which are incorporated by reference This article. Background technique [0003] Hepatic encephalopathy is confusion, altered level of consciousness, and eventually coma that occurs as a result of liver failure. The liver normally functions to remove toxins from the bloodstream, however when it fails it is unable to remove toxins from the bloodstream thus exposing the brain to neurotoxic components of the bloodstream which can lead to confusion, level of consciousness Alteration and eventual coma. [0004] The primary source of toxins filtered by a healthy liver is the gastrointestinal tract, which produces toxins as byproducts of ingested food, other ingested substances, and gastrointestinal flora. Therefore, the mainstay of treatment for liver failure is to...

AI Technical Summary

Problems solved by technology

The liver normally functions to remove toxins from the bloodstream, however when it fails it is unable to remove toxins from the bloodstream thus exposing the brain to neurotoxic components of the bloodstream which can lead to confusion, level of consciousness change and eventual coma