Preparation method of a novel magnetic self-assembled three-dimensional paper chip

Abstract

The invention relates to a preparation method of a three-dimensional paper chip, in particular to a preparation method of a novel magnetic self-assembled three-dimensional paper chip. The preparationmethod comprises the following steps: with hydrophobic magnetic ink, carrying out screen printing to obtain a channel layer, a pretreatment reagent layer and a detection layer of the paper chip separately; printing a pretreatment agent on the pretreatment reagent layer with a squeegee through patterned reagent printing silk screen; printing a detection agent in a detection area on the detection layer with a squeegee through the patterned reagent printing silk screen; and stacking the channel layer, the pretreatment reagent layer and the detection layer in sequence on a pad made of a magnetic material, so as to obtain the three-dimensional paper chip. The preparation method of the novel magnetic self-assembled three-dimensional paper chip provided by the invention adopts a screen printing technology, an additional bonding layer or a glue spraying or printing step is avoided by improving a printing material, and a magnetic material and a hydrophobic material are both used for printing tosimplify the preparation steps and eliminate the risk that glue permeates to block hydrophilic channels.

Description

technical field

[0001] The invention relates to a preparation method of a three-dimensional paper chip, in particular to a preparation method of a novel magnetic self-assembled three-dimensional paper chip. Background technique

[0002] Microfluidic paper chip is a new type of analytical device that processes a fluid channel network on a paper substrate or paper-based material through methods such as water transfer or hydrophilic modification, and can be used for biological and chemical detection and analysis, also known as on-paper Micro-total analysis laboratory. It not only has the advantages of small volume, less reagent consumption, and easy portability of traditional microfluidic chips, but also has the advantages of simple preparation, low cost, and good biocompatibility. It is a new type of micro-analysis technology platform that has emerged in recent years. , has good application prospects in the fields of disease diagnosis, pathogen detection, food safety and envi...

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