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Herba andrographitis and radix sophorae flavescentis preparation with smaller bitter taste and preparation method thereof

A kind of Andrographis paniculata, a smaller technology, applied in the field of medicine, can solve the problems of limited exploration and research, and achieve the effect of improving poor palatability

Inactive Publication Date: 2018-11-23
LUOYANG RUIHUA ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the bitterness of the powder, it is mainly used to treat colibacillosis and pullorum in chickens, which limits the exploration and research in the direction of other animal diseases.

Method used

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  • Herba andrographitis and radix sophorae flavescentis preparation with smaller bitter taste and preparation method thereof
  • Herba andrographitis and radix sophorae flavescentis preparation with smaller bitter taste and preparation method thereof
  • Herba andrographitis and radix sophorae flavescentis preparation with smaller bitter taste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, a kind of preparation method of Andrographis paniculata L., Sophora flavescens preparation that a kind of bitter taste is less, it may further comprise the steps:

[0021] S1. Take 600g of Andrographis paniculata and put it in the extraction equipment, add 4000g of 65% ethanol, turn on the heating equipment to raise the temperature to 40°C, and soak for 6 hours at 40°C, a total of 2 times. The filtrates were combined to recover ethanol, and the filtrate was concentrated to 200 g; the dregs of Andrographis paniculata were recovered, dried, pulverized, and passed through a 60-mesh sieve to obtain Andrographis paniculata powder.

[0022] S2. Take 400g of decoction pieces of Sophora flavescens and put them in the extraction equipment, add 4000g of 65% ethanol, turn on the heating equipment to raise the temperature to 60°C, and dip for 2.5h at 60°C, twice in total. The filtrates were combined to recover ethanol, and the filtrate was concentrated to 130 g; the f...

Embodiment 2

[0026] Embodiment 2, a kind of preparation method of Andrographis paniculata L. and Sophora flavescens preparation that a kind of bitterness is less, it may further comprise the steps:

[0027] S1. Take 700g of Andrographis paniculata medicinal material and put it into the extraction equipment, add 4700g of 65% ethanol, turn on the heating equipment to raise the temperature to 40°C, and soak for 6h at 40°C, a total of 2 times. Combine the filtrates to recover ethanol, and concentrate the filtrate to 230g; recover Andrographis paniculata dregs, dry, pulverize, and pass through a 60-mesh sieve to obtain Andrographis paniculata dregs powder.

[0028] S2. Take 300g of decoction pieces of Sophora flavescens and put them in the extraction equipment, add 3000g of 65% ethanol, turn on the heating equipment to raise the temperature to 60°C, and soak for 2.5h at 60°C, twice in total. The filtrates were combined to recover ethanol, and the filtrate was concentrated to 100 g; the medicina...

Embodiment 3

[0032] Embodiment 3, a kind of preparation method of Andrographis paniculata L. and Sophora flavescens preparation that a kind of bitterness is less, it may further comprise the steps:

[0033] S1. Take 800g of Andrographis paniculata medicinal material and put it into the extraction equipment, add 5300g of 65% ethanol, turn on the heating equipment to raise the temperature to 40°C, and soak for 6 hours at 40°C, a total of 2 times. Combine the filtrates to recover ethanol, and concentrate the filtrate to 270 g; recover Andrographis paniculata dregs, dry, pulverize, and pass through a 60-mesh sieve to obtain Andrographis paniculata dregs powder.

[0034] S2. Take 200g of Sophora flavescens and put it into the extraction equipment, add 2000g of 65% ethanol, turn on the heating equipment to raise the temperature to 60°C, and dip at 60°C for 2.5h, a total of 2 times. The filtrates were combined to recover ethanol, and the filtrate was concentrated to 70 g; the medicinal residues o...

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Abstract

The invention discloses a herba andrographitis and radix sophorae flavescentis preparation with smaller bitter taste and a preparation method thereof. The preparation method comprises the following steps of S1, selecting the medical material of herba andrographitis, putting into extracting equipment, adding 65% ethanol, impregnating for 6h, impregnating for two times, combining filtrates, and concentrating until the final weight is equal to 1 / 3 of the weight of the crude medical material; recycling the medicine residue of the herba andrographitis, airing and crushing; S2, selecting a decoctionpiece of the medical material of radix sophorae flavescentis, adding 65% ethanol, impregnating for 2.5h, impregnating for two times, combining filtrates, and concentrating until the final weight is equal to 1 / 3 of the weight of the crude medical material; recycling the medicine residue of the radix sophorae flavescentis, airing and crushing; S3, combining the concentrated solutions in step 1 andstep 2; S4, selecting a flavoring agent, adding water, stirring, and dissolving; S5, putting the medicine residue of the herba andrographitis and the medicine residue of the radix sophorae flavescentis in step 1 and step 2 into a fluidized bed, spray-drying by the concentrated solution in step 3, spraying-drying by the solution in step 4, and controlling the content of water to be no more than 9.0%, so as to obtain the herba andrographitis and radix sophorae flavescentis preparation with smaller bitter taste. The herba andrographitis and radix sophorae flavescentis preparation has the beneficial effects that the problem of poor palatability of the herba andrographitis and radix sophorae flavescentis preparation is relieved, and a method is provided for exploring the treatment direction ofthe preparation on other animal diseases.

Description

technical field [0001] The invention relates to a preparation method for reducing the bitterness of andrographis paniculata and sophora flavescens preparations, in particular to a less bitter andrographis paniculata and flavescens preparations and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Andrographis paniculata is the dry aerial part of Andrographis paniculata. Harvest in early autumn when the stems and leaves are lush, and dry. The stem of Andrographis paniculata is square column-shaped, multi-branched, 50-70cm long, and the nodes are slightly enlarged; the quality is brittle and easy to break. The leaves of Andrographis paniculata are shrunken and fragile, and the intact ones are lanceolate or egg-shaped lanceolate, 3-12cm long, 2-5cm wide; the upper surface is gray-green, and both sides are smooth. Slight gas, extremely bitter taste. The main ingredients are andrographolide and dehydrated andrographolide,...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61K9/14A61P31/04A61P1/00
CPCA61K9/145A61K36/19A61K36/489A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P1/00A61P31/04A61K2300/00
Inventor 王永永李新李阳
Owner LUOYANG RUIHUA ANIMAL HEALTH PROD
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