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Use of Niacinamide in Prevention of Salivary Gland Radiation Injury

A technology for radiation damage and salivary glands, which is applied in the field of medicine and health, can solve the problems of short-term effect and difficulty in application, and achieve the effects of preventing radiation damage, improving survival rate, and reducing cell apoptosis

Active Publication Date: 2021-01-15
THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the advancement of radiotherapy technology, the degree of salivary gland radiation damage has been alleviated, and clinicians are also seeking some other means to protect the function of salivary glands, such as the application of artificial saliva, the development of salivary gland transplantation, etc., but These methods did not fundamentally change the decline in salivary gland function after irradiation
It has been reported that in animal experiments, gene transduction was used to treat salivary gland radiation injury, and a certain curative effect was achieved, but its effect is relatively short-term, and it is difficult to apply it clinically in the short term

Method used

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  • Use of Niacinamide in Prevention of Salivary Gland Radiation Injury
  • Use of Niacinamide in Prevention of Salivary Gland Radiation Injury
  • Use of Niacinamide in Prevention of Salivary Gland Radiation Injury

Examples

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Effect test

Embodiment 1

[0027] Example 1: Experimental research on the prevention of radiation injury of submandibular gland cells of neonatal rats by NAM

[0028] 1. Purpose

[0029] To explore the prevention and treatment effect of NAM on radiation injury of submandibular gland cells in rats.

[0030] 2. Materials and methods

[0031] In this example, primary cultured neonatal rat submandibular gland cells in the third-generation logarithmic growth phase were randomly divided into blank group (Control, abbreviated as Cont), pure NAM group (NAM), simple radiation group (IR) and NAM pretreatment group (NAM+IR), 5GyX-ray irradiation with RS2000 biological X-ray irradiator (before irradiation, NAM intervention group (pure NAM group and NAM pretreatment group) were pretreated with 50μM and 200μM NAM for 30min respectively, of which 50μM NAM pretreatment for 30 min: pre-incubating primary cultured submandibular gland cells of neonatal rats with 50 μM nicotinamide for 30 min; Radiation group) only give...

Embodiment 2

[0039] Example 2: Experimental research on the prevention of radiation injury of rat submandibular gland tissue by NAM

[0040] 1. Purpose

[0041] To explore the prevention and treatment effect of NAM on radiation injury of submandibular gland tissue.

[0042] 2. Materials and methods

[0043]In this study, 24 Wistar rats (body weight 180-230g, male or female) were randomly divided into blank group (Control, abbreviated as Cont), pure NAM group (NAM), simple radiation group (IR) and NAM pretreatment group ( NAM+IR), with RS2000 biological X-ray irradiator line 20GyX-ray irradiation (half an hour before irradiation, NAM intervention group (simple NAM group and NAM pretreatment group) were given NAM500mg / kg by intragastric administration, control group (blank group) group and simple radiation group) were only given an equal volume of normal saline). Seven days later, the submandibular gland tissue was taken under anesthesia, paraffin sections were made, and HE staining was p...

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Abstract

The invention discloses new application of nicotinamide to the aspect of preventing sialaden radiation damage, and belongs to the field of medicine and health. The effect that NAM can effectively prevent sialaden radiation damage is finally confirmed through cell and animal experiments. NAM can be prepared to be a drug for preventing sialaden radiation damage, and a new method is provided for clinic treatment of radiative sialaden damage.

Description

technical field [0001] The invention relates to a new application of nicotinamide in preventing radiation damage to salivary glands, and belongs to the field of medicine and health. Background technique [0002] Nicotinamide (Nicotinamide, NAM), also known as nicotinamide, is an amide compound of niacin, a derivative of vitamin B3, and a component of coenzyme I and coenzyme II in human energy metabolism. Its structure is shown in formula (I) Show: [0003] [0004] In clinical practice, NAM is used for the prevention and treatment of pellagra, stomatitis, and glossitis, as well as the treatment of arrhythmias associated with coronary heart disease, viral myocarditis, rheumatic heart disease, and a few digitalis poisoning. Currently, patent CN106715455A (China) has described that nicotinamide riboside drugs can be used to treat subjects suffering from or susceptible to mitochondrial diseases or disorders, or to increase the risk of insulin resistance, metabolic syndrome, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/455A61P1/00
CPCA61K31/455A61P1/00
Inventor 向彬王馨悦
Owner THE SECOND HOSPITAL OF DALIAN MEDICAL UNIV