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A temperature-controllable easily degradable temperature-sensitive polymer and its preparation method

A temperature-sensitive polymer, easy to degrade technology, applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problem that the phase transition temperature cannot be adjusted at will, the bioavailability of drugs is low, and the temperature-sensitive polymer is not degradable To achieve the effect of improving the utilization rate of drugs, meeting the requirements of industrial production, and being easy to control the temperature

Active Publication Date: 2021-01-29
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In view of the fact that the existing thermosensitive polymers are not degradable, and their phase transition temperature cannot be adjusted arbitrarily, when used as a drug carrier, it will lead to defects such as low bioavailability of the drug by the human body; the first purpose of the present invention is to Provide a fully biodegradable temperature-sensitive biodegradable polymer that can precisely regulate the phase transition temperature by changing the length of the main chain, the molecular weight of oligopolyethylene glycol, and the ratio of oligopolyethylene glycol and isopropylamide groups. Sexual polymer, the phase transition temperature of the temperature-sensitive polymer can be controlled at a temperature closer to human body temperature, and when used as a drug carrier, it is beneficial to control the release rate of the drug and improve the utilization rate of the drug

Method used

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  • A temperature-controllable easily degradable temperature-sensitive polymer and its preparation method
  • A temperature-controllable easily degradable temperature-sensitive polymer and its preparation method
  • A temperature-controllable easily degradable temperature-sensitive polymer and its preparation method

Examples

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Effect test

Embodiment 1

[0050] 1. Preparation of polylactide containing norbornene side groups:

[0051] First, the ampoule was repeatedly baked 3 times under vacuum, then, 3 g of norbornene-functionalized lactide monomer was added to the ampoule under argon gas, and 0.1 g of catalyst TBD was added with a steel spoon at the same time. , inject 3 ml of refined dichloromethane containing the initiator anhydrous methanol prepared in advance, react at room temperature for 24 h, and then use anhydrous methanol as a sedimentation agent to settle once to obtain a polypropylene containing norbornene side groups. Lactide, which has a degree of polymerization of 16 (ie, n=16). Its structure was characterized by hydrogen NMR spectroscopy ( figure 1 ),The molecular weight distribution( Image 6 A), indicating that the polymer was successfully synthesized.

[0052] 2. Preparation of polylactide-g-polyethylene glycol monomethyl ether copolymer:

[0053] Add 2 g of the obtained polylactide containing norbornene...

Embodiment 2

[0061] Other steps and experimental conditions are as in Example 1, except that the end-group azide-modified polyethylene glycol monomethyl ether 550 is replaced with end-group azide-modified polyethylene glycol monomethyl ether 350 or end-group azide-modified polyethylene glycol monomethyl ether 350. Ethylene glycol monomethyl ether 750. The relationship between the transmittance and temperature of the prepared polylactide-g-polyethylene glycol monomethyl ether copolymer containing pendant isopropyl amide groups in water is as follows Figure 8 shown.

Embodiment 3

[0063] Other steps and experimental conditions are the same as in Example 1, except that the molar ratios of polyethylene glycol monomethyl ether 550 modified with terminal azide and isopropyl amide groups were adjusted to 1:0.38; 1:0.51; 1:0.68; 1:1.04; 1:1.36; 1:1.45. The relationship between the transmittance and temperature of the prepared polylactide-g-polyethylene glycol monomethyl ether copolymer containing pendant isopropyl amide groups in water is as follows Figure 9 shown.

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Abstract

The invention discloses a temperature-controllable easily degradable temperature-sensitive polymer and a preparation method thereof; the preparation method of the temperature-sensitive polymer is to obtain norbornene-containing lactide by ring-opening polymerization of norbornene-functionalized lactide. The polylactide main chain polymer of alkenyl side group is obtained by first grafting oligomeric polyethylene glycol monomethyl ether on the main chain polymer, and then modifying the amide group. The method has the advantages of simple operation, mild reaction conditions and few side reactions, and the prepared temperature-sensitive polymer not only is easy to control the phase transition temperature, but also has good biocompatibility and easy degradability, and has wide potential application prospects.

Description

technical field [0001] The invention relates to a functional polymer material, in particular to a temperature-controllable easily degradable temperature-sensitive polymer and a preparation method thereof, and belongs to the field of polymer biological material preparation. Background technique [0002] Stimuli-responsive polymers are currently a hot research topic, and they can respond to single or multiple stimuli, such as temperature, pH, electromagnetic fields, light, stress, and microbial stimuli. Temperature sensitivity is one of the most interesting properties of stimuli-responsive polymers. Reasons why thermosensitive polymers are most widely studied: There is a wide variety of thermosensitive materials available; temperature is also the safest, most controllable and achievable external stimulus. Common temperature-sensitive polymers are poly(meth)acrylamide, poly[oligo(ethylene glycol)(meth)acrylate], polyaminoethylmethacrylate, and the like. The temperature-sensit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/00A61K47/34
CPCA61K47/34C08G81/00
Inventor 张雪飞张盼甜
Owner XIANGTAN UNIV
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