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Temperature controllable type easily-degradable thermosensitive polymer and preparation method thereof

A temperature-sensitive polymer and easily degradable technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, etc. and other problems, to achieve the effect of improving the utilization rate of drugs, meeting the requirements of industrial production, and being easy to control the temperature.

Active Publication Date: 2018-12-21
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In view of the fact that the existing thermosensitive polymers are not degradable, and their phase transition temperature cannot be adjusted arbitrarily, when used as a drug carrier, it will lead to defects such as low bioavailability of the drug by the human body; the first purpose of the present invention is to Provide a fully biodegradable temperature-sensitive biodegradable polymer that can precisely regulate the phase transition temperature by changing the length of the main chain, the molecular weight of oligopolyethylene glycol, and the ratio of oligopolyethylene glycol and isopropylamide groups. Sexual polymer, the phase transition temperature of the temperature-sensitive polymer can be controlled at a temperature closer to human body temperature, and when used as a drug carrier, it is beneficial to control the release rate of the drug and improve the utilization rate of the drug

Method used

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  • Temperature controllable type easily-degradable thermosensitive polymer and preparation method thereof
  • Temperature controllable type easily-degradable thermosensitive polymer and preparation method thereof
  • Temperature controllable type easily-degradable thermosensitive polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1. Preparation of polylactide containing norbornene side groups:

[0050] First, bake the ampere flask 3 times under vacuum conditions, then, add 3g of norbornene functionalized lactide monomer into the ampere flask under argon gas, and add 0.1g of catalyst TBD with a steel spoon. , Inject 3ml of refined dichloromethane containing initiator anhydrous methanol prepared in advance, react at room temperature for 24h, then use anhydrous methanol as a settling agent, settling once to obtain a polypropylene containing norbornene side groups The degree of polymerization of lactide is 16 (that is, n=16). Its structure is characterized by the hydrogen nuclear magnetic spectrum ( figure 1 ),The molecular weight distribution( Image 6 A), indicating that the polymer was successfully synthesized.

[0051] 2. Preparation of polylactide-g-polyethylene glycol monomethyl ether copolymer:

[0052] Add 2 g of the obtained polylactide containing pendant norbornene groups into a clean ampere fl...

Embodiment 2

[0060] Other steps and experimental conditions are as in Example 1, except that the end group azide modified polyethylene glycol monomethyl ether 550 is replaced with end group azide modified polyethylene glycol monomethyl ether 350 or end group azide modified poly Ethylene glycol monomethyl ether 750. The relationship between the transmittance and temperature of the prepared polylactide-g-polyethylene glycol monomethyl ether copolymer containing isopropylamide side groups in water is as follows Figure 8 Shown.

Embodiment 3

[0062] Other steps and experimental conditions are the same as in Example 1, except that the molar ratio of end group azide modified polyethylene glycol monomethyl ether 550 and isopropyl amide group is adjusted to 1:0.38; 1:0.51; 1:0.68; 1:1.04; 1:1.36; 1:1.45. The relationship between the transmittance and temperature of the prepared polylactide-g-polyethylene glycol monomethyl ether copolymer containing isopropylamide side groups in water is as follows Picture 9 Shown.

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Abstract

The invention discloses a temperature controllable type easily-degradable thermosensitive polymer and a preparation method thereof. The thermosensitive polymer preparation method comprises the steps:performing ring opening polymerization on norbornene functionalized lactide to obtain polylactide main chain polymer containing norbornene side groups, grafting oligopolymerization methoxypolyethyleneglycol at first and then modifying amide groups to obtain the temperature controllable type easily-degradable thermosensitive polymer. The method has the advantages of simpleness in operation, moderation reaction conditions and little side reaction; a phase change temperature of the prepared thermosensitive polymer is easy to regulate; furthermore, the prepared thermosensitive polymer has the advantages of very good biocompatibility, easiness in degradability and wide potential application prospect.

Description

Technical field [0001] The invention relates to a functional polymer material, in particular to a temperature-controllable and easily degradable temperature-sensitive polymer and a preparation method thereof; it belongs to the field of polymer biomaterial preparation. Background technique [0002] Stimulus-responsive polymers are a hot spot in current research. They can respond to single or multiple stimuli, such as temperature, pH, electromagnetic field, light, stress, and microbial stimuli. Temperature sensitivity is one of the most interesting properties of stimulus-responsive polymers. The reason for the most extensive research on temperature-sensitive polymers: the available temperature-sensitive materials are diverse; temperature is also the safest, most controllable and achievable external stimulus. Common temperature-sensitive polymers are poly(meth)acrylamide, poly[oligo(ethylene glycol)(meth)acrylate], polyaminoethyl methacrylate and so on. The temperature-sensitive p...

Claims

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Application Information

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IPC IPC(8): C08G81/00A61K47/34
CPCA61K47/34C08G81/00
Inventor 张雪飞张盼甜
Owner XIANGTAN UNIV
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