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Low-density lipoprotein adsorption microspheres, preparation method and adsorption material
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A low-density lipoprotein and adsorption microsphere technology, which is applied in the field of low-density lipoprotein adsorption microspheres, preparation methods and adsorption materials, can solve the problems of severe reinfusion in fat-removed patients, expensive antibodies, and limited promotion. Suitable for large-scale promotion and application, high adsorption selectivity, fast filtration effect
Active Publication Date: 2019-07-05
广州达济医学科技有限公司
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The ionic adsorbent is represented by cellulose sulfate dextran adsorbent (patent No. JP61165330), which can adsorb LDL through the interaction of its own negative charge with the LDL receptor binding area, but cellulose sulfate dextran can activate the twelfth Coagulation factor, clinical application needs to be cautious; immunosorbent (Patent No. CA2001358) couples LDL antibody to the surface of the adsorption material to make it specifically adsorb LDL, with high adsorption selectivity and obvious adsorption effect, but the antibody is expensive and difficult to store , limiting promotion
[0005] The above-mentioned materials are all aimed at the removal of LDL in centrifuged plasma. After removing LDL, the centrifuged red blood cells and filtered plasma need to be returned to the fat-removed patient. Blood coagulation factors, platelets, white blood cells, etc. are also filtered and isolated, resulting in severe transfusion reactions in fat-removed patients
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[0028] A) 10ml porous polyvinyl alcohol microspheres are placed in the conical flask, and the concentration of 10mlDMSO, 10ml is added successively to be 1.0mol / L sodium hydroxide solution, 5ml of 1,4-butanediol diglycidyl ether, At 30°C for 6 hours, after the reaction is complete, filter with suction, wash with 50% acetone until 1,4-butanediol diglycidyl ether remains, and then wash with distilled water until no acetone remains;
[0029] B) Add 5ml DMSO, 5ml of 1.5mol / L sodium hydroxide solution, 0.12g of δ-tocopherol and 1.88g of α-tocopherol to the porous polyvinyl alcohol microspheres after the above treatment, at 35°C Stir and react for 12 hours, rinse with ethanol solution after the reaction is completed, and then wash with distilled water;
[0030] C) Add 10 ml of distilled water, 5 ml of 0.1 mol / L sodium hydroxide solution and 2 g of sulfonated dextran to the porous polyvinyl ...
[0032] The difference between Example 2 and Example 1 is that 0.1 g of δ-tocopherol and 1.9 g of α-tocopherol are added in step B), and the remaining parameters and operations are as shown in Example 1.
[0034] The difference between Example 3 and Example 1 is that 0.16 g of δ-tocopherol and 1.84 g of α-tocopherol are added in step B), and the remaining parameters and operations are as shown in Example 1.
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Abstract
The invention belongs to the technical field of biological fibers and functional materials and specifically relates to a low density lipoprotein adsorption microsphere and a preparation method and anadsorption material. The low density lipoprotein adsorption microsphere comprises a carrier; a hydrophobic functional group and heparinoid are coupled to the carrier; the mass ratio of the carrier, the heparinoid and the hydrophobic functional group is 1:(0.1-0.5):(0.1-0.5); the hydrophobic functional group consists of Delta-tocopherol and Alpha-tocopherol, wherein the content of the Delta-tocopherol does not exceed 5-8wt%. The low density lipoprotein adsorption microsphere provided by the invention has the advantages that the adsorption selectivity for LDL in whole blood is high, the adsorption rate of the LDL can reach up to 95% and above; more importantly, the damage to erythrocyte is low; the erythrocyte decrement rate is only 3.21%; and meanwhile, the filtering speed is high, the costis low, and the low density lipoprotein adsorption microsphere is suitable for large-scale promotion and application.
Description
technical field [0001] The invention belongs to the technical field of biological fibers and functional materials, and in particular relates to low-density lipoprotein adsorption microspheres, a preparation method and an adsorption material. Background technique [0002] A large number of studies have proved that a large increase in low-density lipoprotein (LDL) in the blood can cause cardiovascular diseases and blood circulation disorders, such as atherosclerosis, cerebrovascular obstruction, etc., and the number of people who die of cardiovascular and cerebrovascular diseases every year is Atherosclerosis is the main pathogenic factor. Therefore, reducing the LDL concentration in the blood of patients can effectively prevent and treat atherosclerosis, and further control and reduce the incidence of cardiovascular and cerebrovascular diseases. [0003] Prior to this, scholars at home and abroad have done a lot of research work in reducing LDL in the blood, such as taking c...
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