Serum exosome protein marker for obstructive sleep apnea-hypopnea syndrome and application thereof

A technology of sleep apnea and protein markers, applied in the field of serum exosome protein markers, can solve problems affecting patients, affecting the accuracy of monitoring results, and not fully revealing, and achieve the effect of improving accuracy and timeliness

Active Publication Date: 2019-01-04
BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV +1
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Problems solved by technology

However, the diagnosis of PSG has the following problems: A. The PSG diagnosis data of OSAHS needs to be analyzed and interpreted by professionals with certain technical training and reviewed by sleep experts certified by the committee. The detection process is complex, time-consuming and expensive, and cannot meet the needs of large-scale clinical screening of OSAHS patients; B. For patients, this diagnostic technology is n

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  • Serum exosome protein marker for obstructive sleep apnea-hypopnea syndrome and application thereof
  • Serum exosome protein marker for obstructive sleep apnea-hypopnea syndrome and application thereof
  • Serum exosome protein marker for obstructive sleep apnea-hypopnea syndrome and application thereof

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[0039] The present invention will be described in detail below with reference to the accompanying drawings, but the scope of the present invention will not be limited thereto.

[0040] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present invention belongs. All publications specifically mentioned in this article are for all purposes including describing and disclosing the chemical substances, instruments, statistical analysis and methods reported in the publications that may be used in conjunction with the present invention, and are adopted in their entirety. Reference is incorporated into this article. All references cited in this specification should be regarded as indicative of the state of the art. Nothing in this article should be construed as an admission that the present invention has no rights earlier than those disclosures through the previous inven...

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Abstract

The invention provides a serum exosome protein marker for obstructive sleep apnea-hypopnea syndrome and application thereof, and particularly provides application of a detection reagent of the proteinmarker in preparing a kit for detecting the obstructive sleep apnea-hypopnea syndrome. The protein marker is selected from C-reactive protein, haptoglobin and fibronectin; the kit detects the concentration of a protein marker in a subject serum exosome, and compared with normal comparison, the concentration of the C-reactive protein and the concentration of the haptoglobin are increased and/or the concentration of the fibronectin is reduced in the subject serum exosome, and therefore the probability of the obstructive sleep apnea-hypopnea syndrome is indicated to be increased. The invention also provides a related kit and a detection system. The concentration change levels of the three protein markers from the serum exosome can be used for detecting the obstructive sleep apnea-hypopnea syndrome.

Description

technical field [0001] The invention relates to the field of obstructive sleep apnea hypopnea syndrome, in particular to a serum exosome protein marker related to obstructive sleep apnea hypopnea syndrome and its application. Background technique [0002] Among sleep disorders, the most common is Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS). OSAHS is an independent risk factor for cardiovascular and cerebrovascular diseases and is also associated with excessive daytime sleepiness leading to mental decline, mood changes, and increased motor vehicle accidents. The latest "Sleep White Paper" shows that 20.4% of adults in our country suffer from OSAHS. In the United States, uncontrolled moderate-to-severe OSAHS will increase personal health consumption by 2700-3000 US dollars per year, and the total annual economic cost will reach 65-165 billion US dollars. At present, there is still a lack of research on the impact of OSAHS on health consumption in my country, but it is ...

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 魏永祥张慧娜秦彦文
Owner BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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