A nerve fiber model for quality control of magnetic resonance diffusion imaging and its preparation method

A technology of imaging quality and nerve fiber, applied in application, diagnostic recording/measurement, medical science, etc., can solve the problems of long cycle, complicated model making process, no physical model of diffusion imaging fiber, etc., and achieve good simulation effect, The water filling process is convenient and quick

Active Publication Date: 2019-11-29
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Such hydrogen-proton-rich organic solvents (such as hexadecane) are volatile, flammable and toxic as a dispersion medium
In addition, the model making process is complicated and the cycle is long
There are teams in China that use computer simulation methods to develop and apply diffusion imaging models, but there are no reports of diffusion imaging fiber physical models

Method used

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  • A nerve fiber model for quality control of magnetic resonance diffusion imaging and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Firstly, prepare the 3D printed braincase: use the 3T magnetic resonance imaging system T1-mprage sequence to scan the head of healthy human subjects, and obtain the 3D T1 structure image with f resolution of 1mm*1mm*1mm. Then Minics software was used for graphic segmentation, brain tissue was removed from the original image, and the hollow braincase structure was obtained by smoothing. Then convert the brain structure map into a .stl file that can be recognized by 3D printing. Then divide the 3D head-shell diagram into two parts that can be covered up and down along the dividing line 5. The upper part has a shorter distance from the top of the head and the lower part has a larger opening. A glue injection hole 4 with a diameter of 5-10mm. Print the modified .stl file with PLA or SLA material to obtain the skull structure 1, such as figure 1 shown.

[0032]Preparation of spinning: the wall material of the electrospinning fiber is a mixture of PCL and PVP in a mass ra...

Embodiment 2

[0035] The preparation method of the 3D printed braincase is the same as in Example 1, wherein the 3D T1 structure image is obtained by scanning with a 7T magnetic resonance imaging system with a resolution of 0.5mm*0.5mm*0.5mm.

[0036] The preparation of spinning is the same as in Example 1.

[0037] The preparation of the agarose gel and the fixation of the spinning were the same as in Example 1, in which a part of the agar had a mass concentration of 2% for simulating fibrotic brain tumors, and the other agar had a mass concentration of 1.5% for simulating conventional brain tissue. The preparation method is to firstly prepare 2% agar, remove excess gel after the agar is solidified, and retain the desired shape and size of the gel block of the brain tumor. On this basis, electrospun fibers and 1.5% agar were further added.

[0038] All the other steps are the same as in Example 1.

Embodiment 3

[0040] In this example, 0.1 mmol / L manganese chloride and 0.2 mmol / L nickel chloride were added to the agarose gel in Example 1, so that the T1 and T2 values ​​of the agar were closer to human gray matter. In addition, sodium nitrite, an antifungal substance with a mass concentration of 30 mg / kg, was added.

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Abstract

The invention discloses a nerve fiber model for quality control of magnetic resonance diffusion imaging and a preparation method thereof. The model comprises a magnetic resonance compatible container,agarose gel placed in the container and orderly arranged electrospun fibers having a channel structure immobilized in the agarose gel, wherein the mass concentration of the agarose gel is 1-2%, and the outer diameter of the duct of the electrospun fiber with the duct structure is 1-20 microns, and that pipe is filled with water. The spinning fibers with the channel structure are fixed in the agarose gel according to the spatial distribution of the main nerve bundles of the human brain in the human brain.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a nerve fiber model used for quality control of magnetic resonance diffusion imaging and a preparation method thereof. Background technique [0002] Diffusion magnetic resonance imaging is a non-destructive detection technique widely used in basic research and clinical diagnosis of white matter fiber structure. It indirectly describes the morphological and structural characteristics of brain nerve cell axons by detecting the microscopic diffusion movement characteristics of water molecules, and macroscopically reveals the brain network based on fiber structure connections. The brain fiber tract reconstruction technology based on this method is playing an increasingly important role in the research of brain diseases, brain science and neuroscience. [0003] In recent years, with the improvement of hardware performance such as magnetic resonance gradients, diffu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/055
CPCA61B5/055A61B2560/0228
Inventor 丁秋萍张春晨何宏建张明暐孙毅叶慧慧李晨童琪琦彭宇
Owner ZHEJIANG UNIV
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