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Electrostaticspun nanofibrous membrane of controlled-release growth factors and esophageal membrane-coated memory stent

A nanofiber membrane and electrospinning technology, applied in the field of medical devices, can solve problems such as poor treatment of esophageal injury, achieve good mucosal protection, promote repair, and prevent stents from shifting and falling off.

Pending Publication Date: 2019-01-11
SHANGHAI FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The purpose of the present invention is to solve the problem of poor treatment of esophageal injury without esophageal stenosis or obstruction in the prior art, to provide a treatment method for esophageal covered memory stent, and an electrospun nanofiber membrane with controlled release growth factors and esophageal Covered memory stent

Method used

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  • Electrostaticspun nanofibrous membrane of controlled-release growth factors and esophageal membrane-coated memory stent
  • Electrostaticspun nanofibrous membrane of controlled-release growth factors and esophageal membrane-coated memory stent
  • Electrostaticspun nanofibrous membrane of controlled-release growth factors and esophageal membrane-coated memory stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1 Esophagus coated memory stent of the present invention (1)

[0049] See figure 1 , figure 1 It is the front view of the memory stent covered with esophagus in Example 1 (in a fully released state). The two ends of the esophagus-covered memory stent are a first fixed end 1 and a second fixed end 2 respectively, and a stent main body 3 is located between the first fixed end 1 and the second fixed end 2 . The stent main body 3 is braided by memory metal wires and is in the shape of a cylindrical tube with an outer diameter of 40-50 mm. The second fixed end 2 is also braided by memory metal wires and is in the shape of a trumpet, and the outer diameter of the lower edge is 52-56mm. The memory wire of the second fixed end 2 and the bracket body 3 is an integrated structure. The entire outer wall of the second fixed end 2 and the stent main body 3 is covered with a film 4 containing growth factors. The first fixed end 1 is composed of several diaphragms 5; t...

Embodiment 2

[0054] Embodiment 2 Esophagus coated memory stent of the present invention (2)

[0055] Please refer to image 3 , image 3 It is the front view of the memory stent covered with esophagus in Example 2 (in a fully released state). The two ends of the esophagus-covered memory stent are a first fixed end 1 and a second fixed end 2 respectively, and a stent main body 3 is located between the first fixed end 1 and the second fixed end 2 . The stent body 3 is braided by memory metal wires and is in the shape of a cylindrical tube with an outer diameter of 40-50 mm. The upper edge of the stent body 3 is wave-shaped and provided with several grooves 6 . The second fixed end 2 is also braided by memory metal wires and is in the shape of a trumpet, and the outer diameter of the lower edge is 52-56mm. The memory wire of the second fixed end 2 and the bracket body 3 is an integrated structure. The entire outer wall of the second fixed end 2 and the stent main body 3 is covered with a ...

Embodiment 3

[0057] Embodiment 3 Electrospinning nanofiber membrane of the present invention (1)

[0058] (a) Preparation of electrospinning solution: the shell layer solution is polylactide caprolactone copolymer (75:25) solution with hexafluoroisopropanol (purchased from Merck) as the solvent, the concentration is 0.08g / mL, and the core layer The solution uses ultrapure water as a solvent, the solute is recombinant human EGF protein (purchased from Gibco, product number PHG0315), and the protein concentration is 20 ng / ml;

[0059] (b) Coaxial co-spinning: At an ambient temperature of 18-20°C and a humidity of 45-50%, after the shell and core solutions are completely dissolved and uniform, inject the shell solution and core solution into coaxial electrospinning In the two injectors of the equipment (SS-2535, Beijing Yongkang Leye Technology Development Co., Ltd.), the spinning voltage is 15kV, the distance from the nozzle to the receiving device is 15cm, and the steady flow rate of the sh...

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Abstract

The invention relates to an electrospun nanofibrous membrane of controlled-release growth factors and an esophageal membrane-coated memory stent. The electrospun nanofibrous membrane of controlled-release growth factors is characterized in that the housing solution is a poly (caprolactone lactate) copolymer solution with hexafluoroisopropanol as a solvent; the core solution is an aqueous solutionof EGF protein, and is prepared by a coaxial co-spinning method. The esophageal membrane-coated memory stent comprises a first fixed end, a second fixed end and an outer diameter of 40-50 mm stent body, a second fixing end and an entire outer wall of the stent body coated with the controlled-release growth factor electrospun nanofiber membrane, and the first fixing end is composed of a plurality of membrane sheets with tension. The invention provides a novel method for treating esophageal injury without stenosis or obstruction. The esophageal membrane-coated memory stent can be used for esophageal injury without stenosis or obstruction and is not easy to dislocate. The electrospun nanofiber membrane loaded by the memory stent has excellent sustained release effect and good protein activity, and can remarkably promote the repair of esophageal injury.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to an electrospun nanofiber membrane for controlled release of growth factors and an esophagus-covered memory support. Background technique [0002] Esophageal stent is the most commonly used tool in the treatment of various benign and malignant esophageal diseases. Its functions include internal support, which can effectively relieve esophageal obstruction, prevent the occurrence of esophageal stenosis, facilitate eating and nutrition, and help recovery of physical function. Esophageal stents usually need to be left in the patient's body for a certain period of time. The general principle of placing these esophageal stents is that after the stent is placed, the expanded stent is stuck in the stenosis because of its own memory expansion force, making it difficult to move the position. [0003] In some patients without obvious stenosis or obstruction, other parts of their es...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/90A61M31/00A61L31/10A61L31/16
CPCA61L31/10A61L31/16A61M31/00A61F2/90A61L2300/602A61L2300/414C08L67/04C08L89/00
Inventor 宛新建张伟星
Owner SHANGHAI FIRST PEOPLES HOSPITAL
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