A micron-scale hollow mesoporous SIO 2 Anticoagulant water medical silicone material modified by blending microspheres and pdms

Abstract

The invention discloses a micron-scale hollow mesoporous SiO 2 Anti-coagulation water medical silica gel material modified by blending and cross-linking of microspheres and PDMS, using a new type of micron-scale reactive hollow mesoporous SiO 2 The microspheres are used as a cross-linking agent and blended with polydimethylsiloxane (PDMS), the current silicone rubber substrate for ventilator pipes, to obtain a porous microsphere-doped silicone rubber substrate with stable performance. mesoporous hollow SiO 2 The microspheres can not only play the role of thermal insulation, but also load small molecule antibacterial agents in them. The mesoporous shell layer makes the antibacterial agents slowly release in the substrate, and plays a role of pipeline antibacterial. Finally, a layer of nanoscale SiO was immobilized in situ on the surface of silica gel. 2 The super-hydrophilic layer of particles inhibits the formation of water droplets on the surface, thereby preparing a new type of medical silicone rubber material integrating thermal insulation, anti-coagulation and antibacterial functions.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to a micron-scale hollow mesoporous SiO 2 Microspheres and PDMS blended cross-linked modified anti-coagulation water medical silica gel material. Background technique [0002] With the rapid development of intensive care medicine, mechanical ventilation plays an important role in the treatment of critically ill patients. However, in the process of mechanical ventilation with a ventilator, due to the heating and humidification of the inhaled gas and the temperature difference between the exhaled gas and the environment, a large amount of condensed water (800-1000ml / day) is often produced in the breathing circuit. Condensed water directly enters the pipeline or respiratory tract, causing the pipeline to accumulate water, causing the ventilator to be triggered by mistake, and the human-machine confrontation to increase, which in turn increases the respiratory load of the pat...

AI Technical Summary

Problems solved by technology

However, the above-mentioned methods have shortcomings, such as the difficulty in achieving precise temperature control, the heating guide wire is not placed in the exhaust pipeline, and the water collection cup is prone to be tilted or inverted when changing positions and nursing operations for critically ill patients.

The concentration of bacteria in the condensed water close to the conduit can be as high as 2*10 5 cfu / ml, increased the incidence of ventilator-associated pneumonia, and brought great difficulties to the prevention and control of medical infection

The above situation can lead to a series of problems such as prolonging the hospital stay of ICU patients, increasing the cost of treatment, and increasing the workload of medical care, which will bring a heavy burden to the patient's family and the society. One of the problems that is avoided but needs to be solved urgently

[0004] At present, no matter whether it is through modifying the water collection cup or inserting the pipeline heating guide wire, the two mainstream methods of reducing pipeline condensate water have little effect in clinical practice. The reason is that the current silicone pipeline material has not been fundamentally solved. The heat insulation effect is poor, so that heat can be exchanged quickly inside and outside the pipeline, resulting in the rapid condensation of moisture in the warm gas in the pipeline, resulting in a large amount of condensed water

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