Beam evaluation method for boron neutron capture therapy, device, apparatus and storage medium

A boron neutron capture and thermal neutron beam technology, applied in the field of beam evaluation methods, devices, equipment and storage media for boron neutron capture therapy, can solve the waste of manpower and material resources, take a long time, and be highly complex Degree and other issues

Active Publication Date: 2019-01-11
国科中子医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the high complexity of the neutron shaping device, it takes a long time to adjust the neutron shaping device each time, resulting in a serious waste of manpower and material resources and low efficiency

Method used

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  • Beam evaluation method for boron neutron capture therapy, device, apparatus and storage medium
  • Beam evaluation method for boron neutron capture therapy, device, apparatus and storage medium
  • Beam evaluation method for boron neutron capture therapy, device, apparatus and storage medium

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Experimental program
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Embodiment 1

[0032] figure 1 It is a flow chart of a beam evaluation method for boron neutron capture therapy provided by Embodiment 1 of the present invention. This embodiment is applicable to various situations of beam evaluation for boron neutron capture therapy, and the method can be implemented by the present invention The example provides a beam evaluation device for boron neutron capture therapy, which can be implemented in the form of software and / or hardware, and can be integrated into any device that provides the beam evaluation function for boron neutron capture therapy. For example, it can be a computer. Such as figure 1 shown, including:

[0033] S110. Separately divide the neutron energy spectrum to be evaluated and the photon energy spectrum to be evaluated in the epithermal neutron beam into multiple sub-spectrum intervals.

[0034] Due to the wide energy range of neutron beams produced after proton targeting, including fast neutrons, thermal neutrons, epithermal neutron...

Embodiment 2

[0057] Figure 2A It is a flowchart of a beam evaluation method for boron neutron capture therapy provided by Embodiment 2 of the present invention. This embodiment also includes a first depth dose formula, a second depth dose formula and a third depth dose formula on the basis of the above embodiment. Construction of the depth dose formula.

[0058] Correspondingly, the method of this embodiment includes:

[0059] S210. Construct a first depth dose formula, a second depth dose formula and a third depth dose formula.

[0060] Wherein, the first depth dose formula includes:

[0061]

[0062] Among them, D i Indicates the total dose rate caused by the neutron spectrum to be evaluated at the normal tissue depth i; R im Indicates the dose rate caused by neutrons in the mth sub-spectrum interval of unit fluence in the preset neutron energy spectrum at the normal tissue depth i; φ m Indicates the neutron fluence in the mth sub-spectrum interval in the neutron energy spectrum...

Embodiment 3

[0094] Figure 3A It is a flow chart of a beam evaluation method for boron neutron capture therapy provided by Embodiment 3 of the present invention. This embodiment is optimized on the basis of the above-mentioned embodiments, and provides an optimized data set passing through the multiple sets of first curves. . The multiple sets of second curve data and the multiple sets of third curve data are used to determine the dominant depth and treatment gain to evaluate the treatment effect of the epithermal neutron beam.

[0095] Correspondingly, the method of this embodiment includes:

[0096] S310. Separate the neutron energy spectrum to be evaluated and the photon energy spectrum to be evaluated in the epithermal neutron beam into multiple sub-spectrum intervals.

[0097] S320. Obtain the fluence of each sub-spectrum interval in the neutron energy spectrum to be evaluated as a first fluence, and obtain the fluence of each sub-energy spectrum interval in the photon energy spectr...

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Abstract

The invention relates to a beam evaluation method for boron neutron capture therapy, a beam evaluation device for boron neutron capture therapy, an apparatus and a storage medium. The method includesthe following steps that: a neutron energy spectrum to be evaluated and a photon energy spectrum to be evaluated in an epithermal neutron beam are separately divided into a plurality of sub-energy-spectrum intervals; the fluence of the sub-energy-spectrum intervals in the neutron energy spectrum to be evaluated is obtained and is adopted as first fluence, and the fluence of the sub-energy-spectrumintervals in the photon energy spectrum to be evaluated is obtained and is adopted as second fluence; the first fluence is substituted into a first depth dose formula and a second depth dose formulaseparately, so that first curve data and second curve data are obtained, and the second fluence is substituted into a third depth dose formula, so that third curve data are obtained; and dominant depth and treatment gain are determined according to the first curve data, the second curve data and the third curve data, so that the therapeutic effect of the epithermal neutron beam is determined. Withthe beam evaluation method for boron neutron capture therapy, the beam evaluation device for boron neutron capture therapy, the apparatus and the storage medium adopted, the evaluation effectivenessof the therapeutic effect of the epithermal neutron beam can be effectively improved, and a neutron shaping device can be quickly adjusted.

Description

technical field [0001] Embodiments of the present invention relate to the technical field of radiotherapy, and in particular to a beam evaluation method, device, equipment and storage medium for boron neutron capture therapy. Background technique [0002] With the rapid development of modern medical technology, boron neutron capture therapy has been widely used in clinical medicine. [0003] BNCT (Boron Neutron Capture Therapy, Boron Neutron Capture Therapy) is a bio-targeted radiotherapy mode with "inherent" safety, by injecting non-toxic boron-containing drugs with pro-tumor tissue into human blood, waiting for boron drugs to After being enriched in tumor tissue, epithermal neutrons are used to irradiate the tumor site. Epithermal neutrons enter human tissue, and after being moderated into thermal neutrons, they can interact with 10 The B nuclide undergoes a radiation capture reaction, releasing α particles ( 4 He) and lithium particles ( 7 Li). Due to the short range...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H20/40
CPCG16H20/40
Inventor 黄红冷志涛
Owner 国科中子医疗科技有限公司
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