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Application of Herba Sarcandrae injection in atomization and rectal administration and preparation method thereof

A technology for rectal administration and injection, which is applied in the field of nebulization and rectal administration of Zhongjiefeng injection and its preparation, and can solve the problems of reducing patient compliance, broken needles, infection, etc.

Inactive Publication Date: 2019-01-15
广东新峰药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical application of Zhongjiefeng injection is administered by intramuscular injection, which has the risk of pain at the injection site, infection, broken needle, etc., and reduces the patient's treatment compliance.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Add an osmotic pressure regulator with a mass fraction of 0.2% to the sarcocarpone injection, and adjust the pH value to 6.3 with a pH regulator, and use an ultrasonic wave or a compression atomizer to make an atomized inhalation preparation from the resulting solution, in the form of an atomized Inhale directly into the respiratory system or cover the respiratory system with a topical spray;

[0015] Wherein, the osmotic pressure regulator is one of sodium chloride, boric acid, glucose and borax.

[0016] Wherein, the pH regulator is hydrochloric acid and sodium hydroxide.

Embodiment 2

[0018] Add a rectal absorption accelerator with a mass fraction of 0.25% to the Sarcorrhizae injection, and adjust the pH value to 6.5 with a pH regulator, and make the resulting solution into a rectal administration preparation or put the resulting solution into a dropper to make a rectal preparation. The drip preparation enters the blood circulation through the rectal vein.

[0019] Wherein, the pH regulator is hydrochloric acid and sodium hydroxide.

[0020] Wherein, the rectal absorption accelerator is one of salicylate, 5-methoxysalicylic acid, surfactant, enamine and its derivatives, and fatty acid.

Embodiment 3

[0022] Add a mass fraction of 0.3% osmotic pressure regulator to the sarcocarpone injection, and adjust the pH value to 6.8 with a pH regulator, put the resulting solution into a dropper to make a rectal drip irrigation preparation, and enter the blood circulation through the rectal vein.

[0023] Wherein, the osmotic pressure regulator is one of sodium chloride, boric acid, glucose and borax.

[0024] Wherein, the pH regulator is hydrochloric acid and sodium hydroxide.

[0025] The pH value and the osmotic pressure of the atomized medicinal liquid and spray medicinal liquid prepared in the present invention, the rectal administration preparation meet the requirements of the physical and chemical properties of the respiratory system and intestinal environment, and have no irritation to the respiratory tract and intestinal tract. The prepared Drugs are given to patients through corresponding medical devices and equipment; through the above different preparations, sarcophagus in...

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Abstract

The invention discloses the application of Herba Sarcandrae injection in atomization and rectal administration and a preparation method thereof. 0.2%-0.3% of osmotic pressure regulator is added into the Herba Sarcandrae injection, a pH value is adjusted to 6.3-6.8 by a pH regulator, and that obtained solution is prepared into an atomized inhalation preparation by an ultrasonic wave or a compression atomizing mechanism, and is directly inhaled into the respiratory system in the form of atomization or cover the respiratory system by a local spraying mode. 0.2-0.3% of a rectal absorption enhanceris added to Herba Sarcandrae injection, and pH value is adjusted to 6.3-6.8, and the obtained solution is prepared into a rectal administration preparation or place the obtained solution into a dropper to prepare a rectal drip irrigation preparation, and entering the blood circulation through a rectal vein. The application and method accord with the physico-chemical property requirements of respiratory system and intestinal environment, have no irritation to respiratory tract and intestinal tract, and the prepared medicine is given to a patient through corresponding medical apparatus and equipment. Through the above different preparations, the Herba Sarcandrae injection can be used to treat various diseases clinically.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to the application of sarcocarp injection in nebulization and rectal administration and its preparation method. Background technique [0002] Zhongjiefeng Injection is produced from Zhongjiefeng, sodium chloride and polysorbate according to the scientific ratio, using advanced technology such as secondary distillation, decoction, and secondary sterilization and filtration. Zhongjiefeng injection, heat-clearing and detoxifying, reducing swelling and dissipating stagnation, used for pneumonia, appendicitis, cellulitis, bacillary dysentery, abscess caused by excessive heat and toxin, combined with Zhongjiefeng tablet for digestive tract cancer, pancreatic cancer, Tumors such as liver cancer. At present, the clinical application of Zhongjiefeng injection is administered by intramuscular injection, which has treatment risks such as pain at the injection site, infecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/08A61K9/72A61P11/04A61P31/14A61P11/00A61P35/00
CPCA61K9/0031A61K9/0078A61K9/08A61K36/185A61P11/00A61P11/04A61P31/14A61P35/00
Inventor 吴少飞何国增蒲显强裘建社徐新锋张西南陈宇
Owner 广东新峰药业股份有限公司
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